Document Detail

Validating optimal function of the closed loop stimulation sensor with high right septal ventricular electrode placement in 'ablate and pace' patients.
MedLine Citation:
PMID:  19629664     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The study aim was to validate the closed loop stimulation (CLS) vs. accelerometer (ACC) rate-responsive sensors with electrodes placed in the right ventricular high septal (RVHS) or right ventricular apical (RVA) lead positions in patients following 'ablate and pace' therapy for persistent atrial fibrillation. METHODS: 'Ablate and pace' patients were randomised to either RVHS or RVA electrode placement with a dual sensor device. A double-blind crossover study comparing CLS vs. ACC rate-response pacing modes was undertaken. Subjects undertook cardiopulmonary testing with constant workload light exercise followed by a ramp protocol in addition to activity of daily living assessments. RESULTS: Twenty subjects (14 male; age, 74 +/- 8 years) were studied. Heart rate increase was greater from lying to sitting with ACC. With mental stress, heart rate increase was greater with CLS. Peak heart rates were similar for stair ascent and descent in ACC mode. With CLS mode, however, the peak heart rate was significantly lower for stair descent. There was no difference between modes in mean response time, oxygen deficit, peak VO(2), VO(2) at anaerobic threshold, peak heart rate, total exercise time and total workload. CLS function was equally optimal at both electrode sites. CONCLUSIONS: CLS rate adaptive pacing is appropriate for 'ablate and pace' patients, and this sensor functions equally well using RVA or RVHS lead positions.
John Silberbauer; Paul S G Hong; Rick A Veasey; Nadeem A Maddekar; Wasing Taggu; Nikhil R Patel; Guy W Lloyd; Neil Sulke
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Validation Studies     Date:  2009-07-23
Journal Detail:
Title:  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing     Volume:  26     ISSN:  1572-8595     ISO Abbreviation:  J Interv Card Electrophysiol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-18     Completed Date:  2009-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708966     Medline TA:  J Interv Card Electrophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM    
Department of Cardiology, Eastbourne General Hospital, East Sussex NHS Trust, Kings Drive, Eastbourne, BN21 2UD, UK.
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MeSH Terms
Cardiac Pacing, Artificial / methods
Catheter Ablation*
Combined Modality Therapy
Cross-Over Studies
Double-Blind Method
Electrodes, Implanted*
Equipment Design
Equipment Failure Analysis
Heart Septum / surgery*
Pacemaker, Artificial*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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