| Validating optimal function of the closed loop stimulation sensor with high right septal ventricular electrode placement in 'ablate and pace' patients. | |
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MedLine Citation:
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PMID: 19629664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The study aim was to validate the closed loop stimulation (CLS) vs. accelerometer (ACC) rate-responsive sensors with electrodes placed in the right ventricular high septal (RVHS) or right ventricular apical (RVA) lead positions in patients following 'ablate and pace' therapy for persistent atrial fibrillation. METHODS: 'Ablate and pace' patients were randomised to either RVHS or RVA electrode placement with a dual sensor device. A double-blind crossover study comparing CLS vs. ACC rate-response pacing modes was undertaken. Subjects undertook cardiopulmonary testing with constant workload light exercise followed by a ramp protocol in addition to activity of daily living assessments. RESULTS: Twenty subjects (14 male; age, 74 +/- 8 years) were studied. Heart rate increase was greater from lying to sitting with ACC. With mental stress, heart rate increase was greater with CLS. Peak heart rates were similar for stair ascent and descent in ACC mode. With CLS mode, however, the peak heart rate was significantly lower for stair descent. There was no difference between modes in mean response time, oxygen deficit, peak VO(2), VO(2) at anaerobic threshold, peak heart rate, total exercise time and total workload. CLS function was equally optimal at both electrode sites. CONCLUSIONS: CLS rate adaptive pacing is appropriate for 'ablate and pace' patients, and this sensor functions equally well using RVA or RVHS lead positions. |
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Authors:
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John Silberbauer; Paul S G Hong; Rick A Veasey; Nadeem A Maddekar; Wasing Taggu; Nikhil R Patel; Guy W Lloyd; Neil Sulke |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Validation Studies Date: 2009-07-23 |
Journal Detail:
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Title: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing Volume: 26 ISSN: 1572-8595 ISO Abbreviation: J Interv Card Electrophysiol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-18 Completed Date: 2009-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708966 Medline TA: J Interv Card Electrophysiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 83-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Eastbourne General Hospital, East Sussex NHS Trust, Kings Drive, Eastbourne, BN21 2UD, UK. johnsilberbauer@lycos.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acceleration* Aged Cardiac Pacing, Artificial / methods Catheter Ablation* Combined Modality Therapy Cross-Over Studies Double-Blind Method Electrodes, Implanted* Equipment Design Equipment Failure Analysis Female Heart Septum / surgery* Humans Male Pacemaker, Artificial* Transducers* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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