| Validated spectrophotometric methods for the determination of amiodarone hydrochloride in commercial dosage forms using p-chloranilic acid and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone. | |
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MedLine Citation:
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PMID: 15352517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two simple, sensitive and economical spectrophotometric methods have been developed for the determination of amiodarone hydrochloride in pure form and commercial dosage form. These methods (A and B) are based on the reaction of amiodarone base as n-electron donor with p-chloranilic acid and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as pi-acceptors to give highly colored complex species which absorb maximally at 535 and 570 nm, respectively. Beer's law is obeyed in the concentration ranges 10.0 - 360.0 and 2.0 - 65.0 microg ml(-1) for methods A and B, respectively. Application of the proposed methods to commercial pharmaceutical tablets are presented. |
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Authors:
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Nafisur Rahman; Nadeem Ahmad Khan; Syed Najmul Hejaz Azmi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry Volume: 20 ISSN: 0910-6340 ISO Abbreviation: Anal Sci Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-09-08 Completed Date: 2004-11-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8511078 Medline TA: Anal Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1231-5 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Aligarh Muslim University, Aligarh-202002 UP, India. cht17nr@yahoo.co.in |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amiodarone
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analysis*,
chemistry Anti-Arrhythmia Agents / analysis*, chemistry Benzoquinones / chemistry* Calibration Dosage Forms Molecular Structure Sensitivity and Specificity Spectrophotometry / methods |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Benzoquinones; 0/Dosage Forms; 1951-25-3/Amiodarone; 84-58-2/dichlorodicyanobenzoquinone; 87-88-7/chloranilic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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