Document Detail

Valdecoxib-induced toxic epidermal necrolysis in a patient allergic to sulfa drugs.
MedLine Citation:
PMID:  12680487     Owner:  NLM     Status:  MEDLINE    
A 55-year-old Caucasian woman with a previously documented sulfa allergy was admitted to the hospital after she developed toxic epidermal necrolysis; she had been taking valdecoxib for 8 days for knee pain. Four days later, her bullous lesions had progressed to 45-50% of her body surface area. She was transferred to a burn unit for aggressive wound care and fluid hydration. Valdecoxib, a cyclooxygenase-2 inhibitor, is a benzenesulfonamide prescribed for arthritis pain and inflammation, and dysmenorrhea. Clinicians should exercise caution when prescribing valdecoxib to patients who are allergic to sulfa drugs.
Denise L Glasser; Susan H Burroughs
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmacotherapy     Volume:  23     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-08     Completed Date:  2003-07-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  551-3     Citation Subset:  IM    
Department of Pharmacy Practice, Bernard J. Dunn School of Pharmacy, Shenandoah University, 1460 University Drive, Winchester, VA 22601, USA.
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MeSH Terms
Drug Hypersensitivity / diagnosis,  therapy*
Epidermal Necrolysis, Toxic / diagnosis,  etiology*,  therapy*
Isoxazoles / adverse effects*
Middle Aged
Sulfonamides / adverse effects*
Reg. No./Substance:
0/Isoxazoles; 0/Sulfonamides; 0/valdecoxib

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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