| Valdecoxib-induced toxic epidermal necrolysis in a patient allergic to sulfa drugs. | |
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MedLine Citation:
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PMID: 12680487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 55-year-old Caucasian woman with a previously documented sulfa allergy was admitted to the hospital after she developed toxic epidermal necrolysis; she had been taking valdecoxib for 8 days for knee pain. Four days later, her bullous lesions had progressed to 45-50% of her body surface area. She was transferred to a burn unit for aggressive wound care and fluid hydration. Valdecoxib, a cyclooxygenase-2 inhibitor, is a benzenesulfonamide prescribed for arthritis pain and inflammation, and dysmenorrhea. Clinicians should exercise caution when prescribing valdecoxib to patients who are allergic to sulfa drugs. |
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Authors:
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Denise L Glasser; Susan H Burroughs |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pharmacotherapy Volume: 23 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-08 Completed Date: 2003-07-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: United States |
Other Details:
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Languages: eng Pagination: 551-3 Citation Subset: IM |
Affiliation:
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Department of Pharmacy Practice, Bernard J. Dunn School of Pharmacy, Shenandoah University, 1460 University Drive, Winchester, VA 22601, USA. dglasser@su.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Drug Hypersensitivity
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diagnosis,
therapy* Epidermal Necrolysis, Toxic / diagnosis, etiology*, therapy* Female Humans Isoxazoles / adverse effects* Middle Aged Sulfonamides / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Isoxazoles; 0/Sulfonamides; 0/valdecoxib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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