| The Val66Met polymorphism of the BDNF gene in anorexia nervosa: New data and a meta-analysis. | |
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MedLine Citation:
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PMID: 21936709 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objectives. The Val66Met polymorphism (rs6265) of the BDNF gene is a non-synonymous polymorphism, previously associated with anorexia nervosa (AN). Methods. We genotyped rs6265 in 235 patients with AN and 643 controls. Furthermore, we performed a systematic review of all case-control and family-based studies testing this SNP in AN, and combined the results in a meta-analysis. Results. The results of the case-control study were non-significant. For the meta-analysis, nine studies were identified (n(cases) = 2,767; n(controls) = 3,322, n(trios) = 53) and included. Primarily, the analyses indicated an association with OR of 1.11 (P = 0.024) in the allelic contrast, and OR of 1.14 (P = 0.025) for the dominant effect of the Met allele. However, additional analyses revealed that the first published study (from those included in the meta-analysis) overly influenced the pooled effect size (possibly due to a phenomenon known as a winner's curse). When this case-control study was replaced by a trio study (n(trios) = 293) performed on a largely overlapping sample, the effect size became smaller and non-significant, both for the allelic contrast (OR = 1.07, P = 0.156) and the dominant effect (OR = 1.07, P = 0.319). The quality of included studies was good and there was no significant heterogeneity across the effect sizes. Conclusions. Our analyses indicate that the BDNF Val66Met variant is not associated with AN at detectable levels. |
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Authors:
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Marek K Brandys; Martien J H Kas; Annemarie A van Elburg; Roel Ophoff; Margarita C T Slof-Op't Landt; Christel M Middeldorp; Dorret I Boomsma; Eric F van Furth; P Eline Slagboom; Roger A H Adan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-21 |
Journal Detail:
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Title: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry Volume: - ISSN: 1814-1412 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120023 Medline TA: World J Biol Psychiatry Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht , Utrecht , The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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