Document Detail

Vagus nerve stimulation therapy: 5-year or greater outcome at a university-based epilepsy center.
MedLine Citation:
PMID:  15519919     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This retrospective study documented long-term outcome of patients receiving vagus nerve stimulation (VNS) therapy for pharmacoresistant epilepsy.
METHODS: Medical charts of 28 patients implanted for 5 years or longer were reviewed for changes in seizure frequency after 1 year of VNS therapy and at follow up, which ranged from 5 to 7 years. Numbers of antiepileptic drugs (AEDs) taken by the patients were also computed at 1 year and follow up. One patient had died and one had discontinued VNS therapy; data were available for 26 patients.
RESULTS: The median percent change in seizure frequency from baseline increased from -28% (P = 0.0053, Wilcoxon signed-rank test) at 12 months to -72% (P < 0.0001) at follow up. Some patients whose seizure frequency was not reduced during the initial 12 months of VNS therapy did experience reductions in seizure frequency during the follow-up period.
CONCLUSION: In this retrospective study, the effectiveness of VNS therapy increased over time. Physicians should be aware that response to VNS therapy may be delayed for some patients.
Marianna V Spanaki; Linda S Allen; Wade M Mueller; George L Morris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Seizure     Volume:  13     ISSN:  1059-1311     ISO Abbreviation:  Seizure     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-02     Completed Date:  2005-01-24     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  587-90     Citation Subset:  IM    
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MeSH Terms
Ambulatory Care*
Anticonvulsants / therapeutic use
Child, Preschool
Electric Stimulation Therapy / methods*
Electrodes, Implanted
Epilepsy / drug therapy,  therapy*
Follow-Up Studies
Outcome Assessment (Health Care)
Retrospective Studies
Vagus Nerve / physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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