| Vagus nerve stimulation therapy: 5-year or greater outcome at a university-based epilepsy center. | |
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MedLine Citation:
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PMID: 15519919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This retrospective study documented long-term outcome of patients receiving vagus nerve stimulation (VNS) therapy for pharmacoresistant epilepsy. METHODS: Medical charts of 28 patients implanted for 5 years or longer were reviewed for changes in seizure frequency after 1 year of VNS therapy and at follow up, which ranged from 5 to 7 years. Numbers of antiepileptic drugs (AEDs) taken by the patients were also computed at 1 year and follow up. One patient had died and one had discontinued VNS therapy; data were available for 26 patients. Results: The median percent change in seizure frequency from baseline increased from -28% (P = 0.0053, Wilcoxon signed-rank test) at 12 months to -72% (P < 0.0001) at follow up. Some patients whose seizure frequency was not reduced during the initial 12 months of VNS therapy did experience reductions in seizure frequency during the follow-up period. CONCLUSION: In this retrospective study, the effectiveness of VNS therapy increased over time. Physicians should be aware that response to VNS therapy may be delayed for some patients. |
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Authors:
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Marianna V Spanaki; Linda S Allen; Wade M Mueller; George L Morris |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Seizure : the journal of the British Epilepsy Association Volume: 13 ISSN: 1059-1311 ISO Abbreviation: Seizure Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-02 Completed Date: 2005-01-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9306979 Medline TA: Seizure Country: England |
Other Details:
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Languages: eng Pagination: 587-90 Citation Subset: IM |
Affiliation:
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Department of Neurology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA. mspanaki@mcw.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Ambulatory Care* Anticonvulsants / therapeutic use Child Child, Preschool Electric Stimulation Therapy / methods* Electrodes, Implanted Epilepsy / drug therapy, therapy* Female Follow-Up Studies Humans Male Outcome Assessment (Health Care) Retrospective Studies Universities Vagus Nerve / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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