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Vagus nerve stimulation reverses ventricular electrophysiological changes induced by hyper-sympathetic nerve activity.
MedLine Citation:
PMID:  25380830     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Vagus nerve stimulation (VNS) has shown therapeutic potential for myocardial infarction-induced ventricular arrhythmias. This study aimed to investigate the effects of VNS on ventricular electrophysiological changes induced by hyper-sympathetic nerve activity. Seventeen open-chest dogs were subjected to left stellate ganglion stimulation (LSGS) for 4 h to simulate a hyper-sympathetic tone. All animals were randomly assigned to VNS group (n = 9) and control group (n = 8). In VNS group, VNS was performed at the voltage causing a 10% decrease of heart rate for hours 3-4 during 4-h of LSGS. During the first 2-h of LSGS, the ventricular effective refractory period (ERP) and action potential duration (APD) were both progressively and significantly decreased; the spatial dispersion of ERP, maximum slope of restitution curve, pacing cycle length of APD alternans were all increased. With LSGS+VNS during next 2 h, there was a significant return of all the changed electrophysiological parameters toward baseline levels. In 8 control dogs that received 4-h of LSGS without VNS, all the parameters were changed progressively but without any reversals. Ventricular fibrillation threshold was higher in VNS group than that in control group (17.3±3.4 V vs. 11.3±3.8 V, P<0.05). The present study demonstrated that VNS was able to reverse LSGS-induced ventricular electrophysiological changes and suppress the occurrence of ventricular fibrillation. This article is protected by copyright. All rights reserved.
Authors:
Jie Huang; Jin Qian; Wei Yao; Neng Wang; Zhenjian Zhang; Chuanbin Cao; Bo Song; Zhuo Zhang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-6
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-8     Completed Date:  -     Revised Date:  2014-11-9    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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