Document Detail

Vagus nerve stimulation may be used in the therapy of myocarditis.
MedLine Citation:
PMID:  19481875     Owner:  NLM     Status:  MEDLINE    
Although a large number of different causes have been identified as leading to myocarditis, inflammation plays a pivotal role in its pathological process. No specific methods are available in the therapy of myocarditis except symptomatic treatment. Vagus nerve stimulation has been found to lower the heart rate and recover the normal heart rhythm which may relieve the cardiac symptoms in myocarditis. Furthermore, the acetylcholine that secreted by vagus nerve stimulation was found to inhibit the production of such inflammatory cytokines as tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta). Based on the above, we hypothesized that vagus nerve stimulation can be used in the therapy of myocarditis and lead to relief of symptoms and inhibition of inflammatory process which may kill two birds with one stone.
Hong Li; Tian-De Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-29
Journal Detail:
Title:  Medical hypotheses     Volume:  73     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-13     Completed Date:  2010-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  725-7     Citation Subset:  IM    
Department of Anesthesiology, Xinqiao Hospital, The Third Military Medical University, Chongqing, China.
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MeSH Terms
Myocarditis / therapy*
Vagus Nerve / physiology*

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