Document Detail


Vagus-dependent disruption of interdigestive canine motility by gastric distension.
MedLine Citation:
PMID:  1616039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine the effect of proximal gastric distension on interdigestive patterns of canine gastrointestinal motility and to examine the role of extrinsic nerves in regulating such an effect. Serosal electrodes were placed on the antrum, duodenum, and jejunum. Animals were studied before and after transthoracic vagotomy or after neural isolation of the entire jejunoileum (extrinsic denervation). Proximal gastric distension for 5 h was provided by inflating with air a thin complaint bag placed into the proximal stomach after the onset of phase III of the migrating motor complex (MMC). Four volumes (0, 1.5, 12.5, and 25 ml/kg) were each tested four times in each animal. In neurally intact animals, gastric distension with volumes of 12.5 and 25 ml/kg consistently abolished the MMC in the antrum (100%), duodenum (96%), and proximal jejunum (greater than or equal to 62%), but less often in distal jejunum (greater than or equal to 25%). After vagotomy, gastric distension did not inhibit cycling of the MMC in the antrum, duodenum, or proximal or distal jejunum. After extrinsic denervation of the jejunoileum, gastric distension inhibited the MMC in the antrum and the duodenum but had no effect in the proximal or distal jejunum. These findings suggest that nonnutrient proximal gastric distension may contribute to postprandial changes in patterns of myoelectric activity in the upper gastrointestinal tract and that this effect is mediated by the vagus nerves.
Authors:
R R Dalton; A R Zinsmeister; M G Sarr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  262     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-29     Completed Date:  1992-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G1097-103     Citation Subset:  IM    
Affiliation:
Digestive Diseases Center, Mayo Medical School, Rochester, Minnesota 55905.
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MeSH Terms
Descriptor/Qualifier:
Animals
Denervation
Digestion / physiology*
Dogs
Gastrointestinal Motility / physiology*
Ileum / innervation,  physiology
Intestine, Small / innervation,  physiology*
Jejunum / innervation,  physiology
Muscle, Smooth / innervation,  physiology
Myoelectric Complex, Migrating / physiology*
Organ Specificity
Stomach / innervation,  physiology*
Vagus Nerve / physiology*
Grant Support
ID/Acronym/Agency:
DK-34988/DK/NIDDK NIH HHS; DK-39337/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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