Document Detail

Vagus Somatosensory Evoked Potentials - A Possibility for Diagnostic Improvement in Patients with Mild Cognitive Impairment?.
MedLine Citation:
PMID:  22759638     Owner:  NLM     Status:  Publisher    
Objective: Vagus somatosensory evoked potentials (VSEP) are far-field potentials probably generated in nuclei of then. vagus in the lower brainstem. They represent a putative, easily applicable method for discrimination between patients with Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy controls (HC). Methods: Thirteen patients with AD, 12 with MCI, and 27 age- and gender-matched HC were investigated by stimulating the cutaneous branch of the n. vagus; 8, 6, and 20, respectively, were included in the main part of the analysis. Results: In fronto-central recordings (electrode positions Fz-F4) a grading from HC over MCI to AD could be found, with a significant linear trend over the three groups and significantly increased latencies of the cognitively impaired patients but no significant difference between MCI and AD. Conclusion: The results indicate that the method of VSEP is able to discriminate between cognitively declined patients and HC, whereas no clear-cut differences were detected between MCI and AD.
Florian G Metzger; Thomas Polak; Yashar Aghazadeh; Ann-Christine Ehlis; Katja Hagen; Andreas J Fallgatter
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-02
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  33     ISSN:  1421-9824     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  289-296     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Psychiatry and Psychotherapy, University Hospital Tuebingen, Tuebingen, Germany.
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