| Vagus nerve preservation selectively restores visceral fat volume in patients with early gastric cancer who underwent gastrectomy. | |
| | |
MedLine Citation:
|
PMID: 21035138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Body weight loss is a well-known complication after gastrectomy, and is mainly due to reduced fat volume. The effect of vagotomy on the postoperative fat volume was investigated in patients with early stage gastric cancer who underwent gastrectomy. METHODS: Subcutaneous fat area (SFA) and visceral fat area (VFA) were separately measured in a computed tomographic (CT) image at the level of the umbilicus using Fat Scan software. The changes in these two fat areas were determined by comparing CT images taken before and more than 6 mo after gastrectomy, and the ratio of postoperative to preoperative fat area was calculated in 77 patients. RESULTS: VFA was reduced significantly greater after total gastrectomy (TG) than distal gastrectomy (DG) (P = 0.0003). In 63 patients who underwent DG, the reduction in VFA, but not in SFA, was significantly less in vagus nerve-preserved than in vagus nerve-nonpreserved cases (59.0% ± 24.2% versus 74.9% ± 28.2%, P = 0.027). If compared in each case, VFA showed a significantly greater decrease than did SFA in vagus-nonpreserving, but not in vagus-preserving, gastrectomy (68.2% ± 37.0% versus 52.7% ± 25.2%, P < 0.0001; 76.3% ± 30.0% versus 74.9% ± 28.2%, P = 0.79). CONCLUSIONS: The vagus nerve has a function to locally regulate the amount of intra-abdominal fat tissue, and selective vagotomy in gastrectomy results in a preferential reduction of visceral fat in gastrectomy. Surgical denervation of vagus may be reconsidered as a reasonable treatment for excessive obesity. |
| | |
Authors:
|
Hideyo Miyato; Joji Kitayama; Akio Hidemura; Hironori Ishigami; Shoichi Kaisaki; Hirokazu Nagawa |
Related Documents
:
|
12629568 - Interactions among the beta2- and beta3- adrenergic receptor genes and total body fat a... 18951248 - Chronic social stress during adolescence in mice alters fat distribution in late life: ... 3565298 - Ultrasonic assessment of body composition in obese adults: overcoming the limitations o... 18258618 - A novel interaction between dietary composition and insulin secretion: effects on weigh... 15102518 - Dietary myo-inositol hexaphosphate prevents dystrophic calcifications in soft tissues: ... 3701458 - Interaction of dietary carbohydrate, ascorbic acid and copper with the development of c... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-22 |
Journal Detail:
|
Title: The Journal of surgical research Volume: 173 ISSN: 1095-8673 ISO Abbreviation: J. Surg. Res. Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-02-13 Completed Date: 2012-04-30 Revised Date: 2012-05-02 |
Medline Journal Info:
|
Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: United States |
Other Details:
|
Languages: eng Pagination: 60-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
|
Department of Surgery, Division of Surgical Oncology, University of Tokyo, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Body Weight / physiology Female Gastrectomy / methods* Humans Intra-Abdominal Fat / physiology*, radiography Male Middle Aged Neoplasm Staging Nutritional Status Postoperative Period Retrospective Studies Stomach Neoplasms / pathology, surgery* Subcutaneous Fat / physiology, radiography Tomography, X-Ray Computed Vagotomy Vagus Nerve / physiology*, surgery* |
| Comments/Corrections | |
Comment In:
|
J Surg Res. 2012 May 1;174(1):85-7
[PMID:
21435656
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lateral Position with the Remaining Lung Uppermost Improves Matching of Pulmonary Ventilation and P...
Next Document: NKT cells: the culprits of sepsis?