Document Detail


Vaginal spermicides and spontaneous abortion of known karyotype.
MedLine Citation:
PMID:  3946389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between spermicide use and spontaneous abortion was examined in a New York City case-control study carried out during 1974-1982. In a series of matched sample analyses, case groups categorized by karyotype of the abortus were compared to a control group of prenatal patients with respect to spermicide use. Spermicide use was defined in terms of proximity to the date of conception of the study pregnancy and duration of the episode of use most recent to the study pregnancy. There was no association between spermicide use defined either in terms of recency or duration of use and chromosomally normal abortions, which comprise about 60% of all spontaneous abortions. Similarly, there was no association between spermicide use and the various types of chromosomally abnormal abortions, with the exception of trisomic abortion. Spermicide use for more than one year at any time prior to conception was more common in the cases aborting trisomic conceptions than in the control group (odds ratio = 1.9, confidence limits = 1.2, 3.0). There was evidence to suggest that the association varied with maternal age and phase of entrance into the study.
Authors:
B Strobino; J Kline; A Lai; Z Stein; M Susser; D Warburton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of epidemiology     Volume:  123     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-03-13     Completed Date:  1986-03-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  431-43     Citation Subset:  IM; J    
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / chemically induced*,  genetics
Adult
Chromosome Aberrations
Female
Humans
Karyotyping
Maternal Age
Monosomy
New York City
Pregnancy
Risk
Socioeconomic Factors
Spermatocidal Agents / administration & dosage,  adverse effects*
Time Factors
Trisomy
Grant Support
ID/Acronym/Agency:
1 RO1 DA 02090/DA/NIDA NIH HHS; 1 RO1 HD 08838/HD/NICHD NIH HHS; 1 RO1 HD 12207/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Spermatocidal Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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