Document Detail


Vaginal spermicides, chromosomal abnormalities and limb reduction defects.
MedLine Citation:
PMID:  6680698     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Each year, 300,000-600,000 U.S. women become pregnant while using vaginal spermicides. Two recent reports hypothesized that offspring from these pregnancies are at increased risk of certain birth defects, particularly limb reduction defects and such chromosomal abnormalities as Down syndrome. In a case-control analysis of data from the Metropolitan Atlanta Congenital Defects Program (MACDP), we studied the teratogenicity of spermicides by comparing their use around the time of conception by mothers of infants with chromosomal abnormalities and limb reduction defects to their use by mothers of infants with birth defects that have not been linked to spermicides. The results do not support the hypothesis that spermicides are teratogenic. For infants whose mothers used spermicides at the time of conception, the relative risk of having Down syndrome was 1.2 and that for other chromosomal abnormalities was also 1.2. The relative risk of limb reduction defects among infants exposed to spermicides in the first trimester was 1.0. None of these risks is statistically significant.
Each year, 300 to 600 million U.S. women become pregnant while using vaginal spermicides. 2 recent reports hypothesized that offspring from these pregnancies are at increased risk of certain birth defects, particularly limb reduction defects and such chromosomal abnormalities as Down's syndrome. In a case control analysis of data from the Metropolitan Atlanta Congenital Defects Program (MACDP), the authors study the teratogenicity of spermicides by comparing their use around the time of conception by mothers of infants with chromosomal abnormalities and limb reduction defects to their use by mothers of infants with birth defects that have not been linked to spermicides. The results do not support the hypothesis that spermicides are teratogenic. For infants whose mothers used spermicides at the time of conception, the relative risk of having Down's syndrome was 1.2 and that for other chromosomal abnormalities was also 1.2. The relative risk of limb reduction defects among infants exposed to spermicides in the 1st trimester was 1.0. None of these risks is statistically significant.
Authors:
J F Cordero; P M Layde
Related Documents :
3558458 - Comparison of operations for coarctation of the aorta in infants.
9160468 - Chemonucleolysis with human stromelysin-1.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Family planning perspectives     Volume:  15     ISSN:  0014-7354     ISO Abbreviation:  Fam Plann Perspect     Publication Date:    1983 Jan-Feb
Date Detail:
Created Date:  1985-03-12     Completed Date:  1985-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0241370     Medline TA:  Fam Plann Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  16-8     Citation Subset:  IM; J    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chromosome Aberrations / chemically induced*
Chromosome Disorders
Female
Humans
Limb Deformities, Congenital*
Pregnancy
Risk
Spermatocidal Agents / adverse effects*
Vaginal Creams, Foams, and Jellies
Chemical
Reg. No./Substance:
0/Spermatocidal Agents; 0/Vaginal Creams, Foams, and Jellies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Suicide in children and adolescents.
Next Document:  Contraception and fertility in the Netherlands.