| Vaginal radical trachelectomy: a valuable fertility-preserving option in the management of early-stage cervical cancer. A series of 50 pregnancies and review of the literature. | |
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MedLine Citation:
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PMID: 15936061 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report the obstetrical results following vaginal radical trachelectomy (VRT), a fertility-preserving surgery in the treatment of early-stage cervical cancer. METHODS: Retrospective review of our first 72 patients treated by a laparoscopic pelvic lymphadenectomy followed by a VRT from October 1991 to October 2003 with regards to their reproductive function. RESULTS: Patients' median age was 32 years old (21-42) and 53 (74%) were nulligravida. A total of 50 pregnancies occurred in 31 women. The majority (66%) had only one pregnancy, 19% had 2 pregnancies and 16% had 3 pregnancies or more. The rate of first trimester miscarriage was 16%, the rate of second trimester miscarriage was (4%) and 2 women (4%) elected to have pregnancy termination. A total of 36 pregnancies (72%) reached the third trimester. Of those, 3 (8%) ended prematurely at <32 weeks gestation, 5 (14%) delivered between 32 and 36 weeks and 28 (78%) delivered at term (>37 weeks). One newborn died of neonatal sepsis from E. coli infection and one died from cardiac malformation (trisomy-18). Seven patients (10%) had infertility problems: 3 from ovulatory causes of which 2 successfully conceived with IVF, one from endometriosis and low sperm count and 3 from probable cervical cause of which one conceived with IUI. One patient had a twin pregnancy following IVF and elected to have embryo reduction and subsequently delivered at 37 weeks. CONCLUSION: Based on our experience, the obstetrical results following VRT for early-stage cervical cancer are very encouraging. The majority of women can anticipate to conceive spontaneously and deliver near term. |
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Authors:
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Marie Plante; Marie-Claude Renaud; Iffath A Hoskins; Michel Roy |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Gynecologic oncology Volume: 98 ISSN: 0090-8258 ISO Abbreviation: Gynecol. Oncol. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-20 Completed Date: 2005-08-16 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 3-10 Citation Subset: IM |
Affiliation:
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Gynecologic Oncology Service, Centre Hospitalier Universitaire de Québec (CHUQ), L'Hôtel-Dieu de Québec, Laval University, 11 Côte du Palais, Quebec City, Canada. marie.plante@crhdq.ulaval.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fertility* Gynecologic Surgical Procedures / methods* Humans Laparoscopy / methods Lymph Node Excision / methods Neoplasm Staging Pregnancy* Pregnancy Outcome Retrospective Studies Uterine Cervical Neoplasms / pathology, surgery* |
| Comments/Corrections | |
Comment In:
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Gynecol Oncol. 2005 Jul;98(1):1-2
[PMID:
15946730
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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