Document Detail

Vaginal progesterone gel for luteal phase support in IVF/ICSI cycles: a meta-analysis.
MedLine Citation:
PMID:  20171629     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether vaginal progesterone gel may result in similar or higher pregnancy rates compared with all other vaginal progesterone forms when used for luteal-phase support.
DESIGN: Meta-analysis of randomized controlled trials using odds ratios (OR) and 95% confidence intervals (CI).
PATIENT(S): Infertile women undergoing IVF or ICSI.
INTERVENTION(S): Vaginal progesterone gel 90 mg once or twice daily versus any other vaginal progesterone form for luteal phase support.
MAIN OUTCOME MEASURE(S): Clinical pregnancy rates.
RESULT(S): Seven randomized controlled trials, involving 2,447 patients, were included in the analysis. No difference was observed in the overall clinical pregnancy rate when comparing vaginal progesterone gel with any other vaginal progesterone form. Moreover, clinical pregnancy rates were similar in protocols using only GnRH agonists and when comparing vaginal gel with the traditional treatment of 200 mg×3 vaginal progesterone capsules.
CONCLUSION(S): This meta-analysis provides solid evidence that no significant difference exists between vaginal gel and all other vaginal progesterone forms in terms of clinical pregnancy rates.
Nikolaos P Polyzos; Christina I Messini; Evangelos G Papanikolaou; Davide Mauri; Spyridon Tzioras; Ahmed Badawy; Ioannis E Messinis
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Publication Detail:
Type:  Journal Article; Meta-Analysis     Date:  2010-02-19
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2010-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2083-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Department of Obstetrics and Gynecology, University Hospital of Larissa, University of Thessalia, Larissa, Greece.
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MeSH Terms
Administration, Intravaginal
Fertilization in Vitro / methods*
Luteal Phase / drug effects*,  physiology
Pregnancy Rate
Progesterone / administration & dosage*
Randomized Controlled Trials as Topic
Sperm Injections, Intracytoplasmic / methods
Vaginal Creams, Foams, and Jellies
Reg. No./Substance:
0/Vaginal Creams, Foams, and Jellies; 57-83-0/Progesterone

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