| Vaginal progesterone as luteal phase support in an IVF/GIFT programme. | |
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MedLine Citation:
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PMID: 1426499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether luteal phase support with vaginal progesterone could improve pregnancy rates in our IVF/GIFT programme, we performed a prospective randomised controlled study. After stimulation with clomiphene citrate/human menopausal gonadotrophin, 123 women received no luteal support and 122 received progesterone pessaries 100 mg b.d. from 48 hours prior to embryo transfer and continued throughout the luteal phase. There was no difference in the pregnancy rate following IVF/ET (6/58 and 10/58 for the pessary and control group respectively), but a significantly higher rate was noted for GIFT (13/34 and 5/42 for the pessary and control group respectively; P less than 0.05). Of interest, only one of the 19 pregnancies using luteal support was extra-uterine, compared with 6/15 in the control group. |
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Authors:
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D W Polson; P A Rogers; J A Krapez; J F Leeton |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 46 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-12-11 Completed Date: 1992-12-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 35-8 Citation Subset: IM |
Affiliation:
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Monash IVF Programme, Infertility Medical Centre, Richmond, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intravaginal Adult Clomiphene / therapeutic use Embryo Transfer / methods Female Fertilization in Vitro / methods* Gamete Intrafallopian Transfer / methods* Humans Luteal Phase / drug effects* Menotropins / therapeutic use Pessaries Pregnancy Pregnancy Outcome Pregnancy, Ectopic / prevention & control Progesterone / therapeutic use* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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57-83-0/Progesterone; 61489-71-2/Menotropins; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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