Document Detail


Vaginal progesterone as luteal phase support in an IVF/GIFT programme.
MedLine Citation:
PMID:  1426499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine whether luteal phase support with vaginal progesterone could improve pregnancy rates in our IVF/GIFT programme, we performed a prospective randomised controlled study. After stimulation with clomiphene citrate/human menopausal gonadotrophin, 123 women received no luteal support and 122 received progesterone pessaries 100 mg b.d. from 48 hours prior to embryo transfer and continued throughout the luteal phase. There was no difference in the pregnancy rate following IVF/ET (6/58 and 10/58 for the pessary and control group respectively), but a significantly higher rate was noted for GIFT (13/34 and 5/42 for the pessary and control group respectively; P less than 0.05). Of interest, only one of the 19 pregnancies using luteal support was extra-uterine, compared with 6/15 in the control group.
Authors:
D W Polson; P A Rogers; J A Krapez; J F Leeton
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  46     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-11     Completed Date:  1992-12-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  35-8     Citation Subset:  IM    
Affiliation:
Monash IVF Programme, Infertility Medical Centre, Richmond, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Administration, Intravaginal
Adult
Clomiphene / therapeutic use
Embryo Transfer / methods
Female
Fertilization in Vitro / methods*
Gamete Intrafallopian Transfer / methods*
Humans
Luteal Phase / drug effects*
Menotropins / therapeutic use
Pessaries
Pregnancy
Pregnancy Outcome
Pregnancy, Ectopic / prevention & control
Progesterone / therapeutic use*
Prospective Studies
Chemical
Reg. No./Substance:
57-83-0/Progesterone; 61489-71-2/Menotropins; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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