Document Detail

Vaginal progesterone as luteal phase support in an IVF/GIFT programme.
MedLine Citation:
PMID:  1426499     Owner:  NLM     Status:  MEDLINE    
To determine whether luteal phase support with vaginal progesterone could improve pregnancy rates in our IVF/GIFT programme, we performed a prospective randomised controlled study. After stimulation with clomiphene citrate/human menopausal gonadotrophin, 123 women received no luteal support and 122 received progesterone pessaries 100 mg b.d. from 48 hours prior to embryo transfer and continued throughout the luteal phase. There was no difference in the pregnancy rate following IVF/ET (6/58 and 10/58 for the pessary and control group respectively), but a significantly higher rate was noted for GIFT (13/34 and 5/42 for the pessary and control group respectively; P less than 0.05). Of interest, only one of the 19 pregnancies using luteal support was extra-uterine, compared with 6/15 in the control group.
D W Polson; P A Rogers; J A Krapez; J F Leeton
Related Documents :
21130429 - Increased thrombin generation measured in the presence of thrombomodulin in women with ...
14667999 - Antiprogestins as a model for progesterone withdrawal.
21203389 - Intermittent screening and treatment versus intermittent preventive treatment of malari...
21190419 - Does nuchal translucency thickness in the first trimester predict gdm onset during preg...
21327969 - Impact of fetal versus perinatal hypoxia on sex differences in childhood outcomes: deve...
21210449 - Challenges in the diagnosis of fetal non-chromosomal abnormalities at 11-13 weeks.
20802509 - Epoprostenol treatment for idiopathic pulmonary arterial hypertension in pregnancy.
6497959 - The role of alcohol in unplanned pregnancy.
2962079 - Vaginal bleeding in pregnancies associated with fetal down syndrome.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  46     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-11     Completed Date:  1992-12-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  35-8     Citation Subset:  IM    
Monash IVF Programme, Infertility Medical Centre, Richmond, Victoria, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Intravaginal
Clomiphene / therapeutic use
Embryo Transfer / methods
Fertilization in Vitro / methods*
Gamete Intrafallopian Transfer / methods*
Luteal Phase / drug effects*
Menotropins / therapeutic use
Pregnancy Outcome
Pregnancy, Ectopic / prevention & control
Progesterone / therapeutic use*
Prospective Studies
Reg. No./Substance:
57-83-0/Progesterone; 61489-71-2/Menotropins; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hysteroscopic diagnosis of ectopic pregnancy.
Next Document:  Platelet-activating factor levels in human follicular and amniotic fluids.