| Vaginal misoprostol vs. concentrated oxytocin plus low-dose prostaglandin E2 for second trimester pregnancy termination. | |
| | |
MedLine Citation:
|
PMID: 10090490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To examine the efficacy of vaginal misoprostol for mid-trimester pregnancy termination. METHODS: This randomized trial compared misoprostol, 200 microg per vaginum q 12 h to a protocol of concentrated oxytocin plus low-dose vaginal prostaglandin E2 suppositories (10 mg q 6 h). Success was defined as an induction-to-delivery interval < or =24 h. RESULTS: Interim analysis of the first 30 (15-misoprostol, 15-concentrated oxytocin) women demonstrated that the 2 groups were similar with regard to indication for delivery, gestational age, and demographic characteristics. Misoprostol was associated with a lower success rate (67 vs. 87%, P = .2), a longer induction-delivery interval (22 h vs. 18 h, P = .09), a higher rate of retained placenta requiring curettage (27 vs. 13%, P = .65), and a higher live birth rate (50 vs. 0%, P = .006). CONCLUSIONS: Compared to a regimen of concentrated oxytocin plus low-dose prostaglandin E2, misoprostol administered as vaginal tablets in a dose of 200 microg q 12 h is not satisfactory for mid-trimester pregnancy termination in an unselected population. |
| | |
Authors:
|
J Owen; J C Hauth |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: The Journal of maternal-fetal medicine Volume: 8 ISSN: 1057-0802 ISO Abbreviation: J Matern Fetal Med Publication Date: 1999 Mar-Apr |
Date Detail:
|
Created Date: 1999-05-06 Completed Date: 1999-05-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9211288 Medline TA: J Matern Fetal Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 48-50 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35233-7333, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortion, Induced* Administration, Intravaginal Adult Dinoprostone / administration & dosage* Female Humans Misoprostol / administration & dosage* Oxytocin / administration & dosage* Pregnancy Pregnancy Trimester, Second |
| Chemical | |
Reg. No./Substance:
|
363-24-6/Dinoprostone; 50-56-6/Oxytocin; 59122-46-2/Misoprostol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Incidence of chromosomopathies and cystic fibrosis mutations in second trimester fetuses with isolat...
Next Document: Prediction of difficult vaginal birth and of cesarean section for cephalopelvic disproportion in ear...