Document Detail


Vaginal misoprostol for second-trimester pregnancy termination after one previous cesarean delivery.
MedLine Citation:
PMID:  19781700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the safety and efficacy of using misoprostol vaginally for second-trimester abortion in women with a single previous cesarean delivery. METHOD: This prospective observational study was carried out at a university hospital in Egypt with 50 pregnant women with 1 previous cesarean delivery; a gestation of at least 16 weeks but less than 20 weeks (group 1) or 20 or more weeks (group 2); and a need to terminate the pregnancy. The regimen was 4 doses of 200 microg of misoprostol applied vaginally every 4 hours daily, with a 12-hour nightly rest from misoprostol applications, until contractions appeared but not for more than 72 hours. The primary outcome was the induction-to-abortion interval. RESULTS: There were no cases of uterine rupture. Abortion within the study protocol occurred in 45 of the 50 women, for a 90% success rate. There was no significant difference in the induction-to-abortion interval between the 2 groups. CONCLUSION: Inducing abortion with lower misoprostol doses appear to be safe and effective throughout the second trimester in women with a single previous cesarean delivery. Larger randomized trials are needed to validate these results.
Authors:
Ahmad H Naguib; Hassan M Morsi; Tamer F Borg; Salah T Fayed; Hosam M Hemeda
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  108     ISSN:  1879-3479     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  48-51     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Ain Shams University Maternity Hospital, Ain Shams University, Cairo, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents, Nonsteroidal / administration & dosage,  adverse effects,  therapeutic use*
Abortion, Induced / adverse effects,  methods*
Administration, Intravaginal
Cesarean Section
Egypt
Female
Gestational Age
Hospitals, University
Humans
Misoprostol / administration & dosage,  adverse effects,  therapeutic use*
Pregnancy
Pregnancy Trimester, Second
Prospective Studies
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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