Document Detail

Vaginal intraepithelial neoplasia: a retrospective analysis of clinical features and colpohistology.
MedLine Citation:
PMID:  20178533     Owner:  NLM     Status:  MEDLINE    
AIM: To analyze the clinical features and colpohistology of women with vaginal intraepithelial neoplasia (VAIN).
METHODS: Patients with VAIN treated at Rajavithi Hospital between April 1986 and October 2007.
RESULTS: Of 68 patients, 52.9% had VAIN2/3. The mean age of patients was 50.85 +/- 13.17 years (range: 22-80). The most common presentation was abnormal cytology. History of prior pelvic radiation, associated neoplasia of the lower genital tract and history of prior hysterectomy were documented in 7.4, 67.6 and 54.4% of patients, respectively. Median intervals from previous lower genital tract neoplasia to current diagnosis of VAIN, and between hysterectomy to diagnosis of VAIN were 23.9 and 29.7 months, respectively. The upper third of the vagina was the most common site of VAIN (86.8%). The most common colposcopic finding was the presence of acetowhite epithelium. Punctation was significantly associated with VAIN2/3 (P < 0.05). Mosaic was rare and found in VAIN3.
CONCLUSION: VAIN can occur at any age and is commonly associated with neoplasia of the lower genital tract. Most patients have disease located in the upper third of the vagina. The most common colposcopic finding is acetowhite epithelium while punctation and mosaic pattern are more prevalent in VAIN2/3.
Sathone Boonlikit; Nattakul Noinual
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  36     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-24     Completed Date:  2010-06-01     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  94-100     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.
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MeSH Terms
Aged, 80 and over
Carcinoma in Situ / complications*,  pathology*,  therapy
Middle Aged
Neoplasm Staging
Retrospective Studies
Vagina / pathology*
Vaginal Neoplasms / complications*,  pathology*,  therapy
Young Adult

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