Document Detail

Vaginal fluid human chorionic gonadotropin for detection of rupture of membranes.
MedLine Citation:
PMID:  19097513     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the accuracy of qualitative and quantitative human chorionic gonadotropin (hCG) assays to detect ruptured amniotic membranes (ROM) in term patients. STUDY DESIGN: We conducted a prospective cohort study enrolling 100 term pregnancies with intact membranes. Samples were collected before and immediately following ROM, and at 2 and 4 hours post-ROM. Quantitative and qualitative hCG assays were performed on all samples. Outcome measures included the detection and measured amount of hCG before and after ROM. Sensitivity, specificity and positive predictive values for the qualitative assays were determined. RESULTS: A total of 98% pre-ROM and 100% post-ROM qualitative assays tested positive with mean quantitative hCG levels of 181.30 mIU/mL and 208.24 mIU/mL, respectively. The qualitative post-ROM sensitivity was 100%; however, the pre-ROM specificity was only 2%. The positive predictive value for detecting ROM was 50%. CONCLUSION: Qualitative and quantitative hCG assays are not useful for determining ROM in term pregnancies.
Ronald Beesley; Naomi Trevino; Michael Smyth; Claire Gould; Randal Robinson
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  53     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  823-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Wilford Hall Medical Center, Lackland Air Force Base, Texas, USA.
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MeSH Terms
Amniotic Fluid / chemistry
Body Fluids / chemistry*
Chorionic Gonadotropin / analysis*
Cohort Studies
Fetal Membranes, Premature Rupture / diagnosis*
Predictive Value of Tests
Vagina / chemistry*
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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