Document Detail

Vaginal fluid beta-human chorionic gonadotropin level in the diagnosis of premature rupture of membranes.
MedLine Citation:
PMID:  16026409     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To determine whether the measurement of beta-human chorionic gonadotropin (beta-HCG) level in the vaginal washing fluid could be useful for the diagnosis of premature rupture of membranes. METHODS: Totally, 120 pregnant women were enrolled in this study. Subjects were divided into four groups [group I, no preterm labor and term delivery (n = 38); group II, preterm labor and term delivery (n = 12); group III, preterm labor and consequent premature delivery (n = 24); group IV, preterm labor with premature rupture of membranes (PROM) and consequent premature delivery (n = 46)]. After irrigating the posterior vaginal fornix with 3 ml of sterile saline and the obtained vaginal washing fluid, we measured beta-HCG levels. RESULTS: The median and range of vaginal fluid beta-HCG levels were 3.60 (0.09-30.52), 4.42 (0.33-10.02), 15.50 (0.25-378.62), and 512.53 (26.95-3507.20) mIU/ml in group I, group II, group III, and group IV, respectively. Vaginal beta-HCG level was significantly higher in patients with PROM followed by premature delivery (group IV) than patients in other groups (P < 0.01). From the receiver operating characteristic curve, 39.8 mIU/ml was set as a cutoff value. Sensitivity, specificity, positive predictive value, and negative predictive value were 95.5, 94.7, 91.3, and 97.3%, respectively. CONCLUSION: Our study demonstrated that the measurement of vaginal fluid beta-HCG may be reliable, simple, and rapid test in diagnosing PROM and used as a adjunctive test in equivocal cases.
Young-Han Kim; Yong-Won Park; Han-Sung Kwon; Ja-Young Kwon; Bok-Ja Kim
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  84     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-19     Completed Date:  2005-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  802-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, College of Medicine, Yonsei University, 134 Shinchoin-Dong, Sedaemun-Ku, Seoul 120-752, Korea.
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MeSH Terms
Biological Markers / analysis
Body Fluids
Chorionic Gonadotropin, beta Subunit, Human / analysis,  metabolism*
Fetal Membranes, Premature Rupture / diagnosis*
Follow-Up Studies
Maternal Age
Predictive Value of Tests
Pregnancy Outcome*
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prospective Studies
Sensitivity and Specificity
Vagina / chemistry*
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human

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