Document Detail

Vaginal expulsion of a submucosal myoma during treatment with long-acting gonadotropin-releasing hormone agonist.
MedLine Citation:
PMID:  17197363     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Gonadotropin-releasing hormone agonist (GnRH agonist) therapy has been useful as an adjunct before myomectomy or hysterectomy for uterine myoma. CASE REPORT: A 26-year-old woman without sexual exposure was diagnosed with a submucosal myoma and treated with long-acting GnRH agonist. This patient exhibited heavy menstruation and severe anemia for 2 years and consulted our outpatient department. Transabdominal ultrasound demonstrated a 3.5-cm submucosal myoma within the endometrial cavity. The patient showed a marked suppression of serum estradiol concentrations throughout the treatment (< 20 pg/mL at the second dose injection). The volume of the uterus and uterine myoma decreased to two-thirds of the original size at the end of the second dose injection. However, a sudden onset of severe abdominal cramping pain occurred on the 76th day and a ping-pong sized mass was expelled from the vagina. She visited our outpatient department for evaluation, where ultrasound failed to detect the previous submucosal uterine myoma. A 3-year follow-up has been uneventful. CONCLUSION: Spontaneous expulsion of submucosal myomas might occur after the administration of GnRH agonist; hence, it may be an acceptable alternative for symptomatic females without sexual exposure.
Lily Wen; Jen-Yu Tseng; Peng-Hui Wang
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Taiwanese journal of obstetrics & gynecology     Volume:  45     ISSN:  1875-6263     ISO Abbreviation:  -     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-01-26     Revised Date:  2007-12-28    
Medline Journal Info:
Nlm Unique ID:  101213819     Medline TA:  Taiwan J Obstet Gynecol     Country:  China    
Other Details:
Languages:  eng     Pagination:  173-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Cardinal Tien Hospital-Hsintien, Taiwan.
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MeSH Terms
Gonadotropin-Releasing Hormone / agonists*
Leiomyoma / drug therapy*
Treatment Outcome
Uterine Neoplasms / drug therapy*
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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