Document Detail

Vaginal delivery of progesterone in donor oocyte therapy.
MedLine Citation:
PMID:  10928428     Owner:  NLM     Status:  MEDLINE    
A prospective cohort study, with 345 women requiring complete progesterone replacement for a donor egg cycle, was used to compare Crinone 8% (90 mg progesterone vaginal gel) twice or once daily versus i.m. progesterone (100 mg), for endometrial development and pregnancy support. Endometrial histology, serum progesterone levels, pregnancy rates, implantation rates, and bleeding patterns were used as outcome measures. Mean serum progesterone concentrations on day 26 were 19.0 + 2.3 ng/ml for twice and 11.3+/-6.5 ng/ml for once daily Crinone, versus 65.2+/-12.5 ng/ml in the i.m. progesterone group. Endometrial histology was 'in phase' for all women in the Crinone groups and most of the i.m. group. Though eight of 42 patients on once daily Crinone had serum progesterone levels under 6 ng/ml, there was no correlation with endometrial development. Only one patient bled on once daily Crinone before the 14th day of progesterone therapy, and she went on to deliver twins. Clinical pregnancy, ongoing pregnancy, implantation, and miscarriage rates were not statistically different among any of the treatment groups. Crinone 8% administered once or twice daily appears to produce the same endometrial development and pregnancy rates as i.m. progesterone in women requiring complete progesterone replacement, and without early bleeding.
J P Toner
Related Documents :
21410408 - Diastolic forward flow in the fetal main pulmonary artery and its implication for fetal...
12866258 - The influence of the ovulation rate on ultrasonically determined ovine corpus luteum mo...
18364378 - Estrogen and progesterone metabolism in the cervix during pregnancy and parturition.
8878708 - Chorion villosum does not express progesterone and estrogen receptors during the first ...
16434458 - Prolonged salivary cortisol recovery in second-trimester pregnant women and attenuated ...
8169908 - Serum from patients with threatened abortion. effect on in vitro development of mouse e...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  15 Suppl 1     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-22     Completed Date:  2000-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  166-71     Citation Subset:  IM    
Jones Institute for Reproductive Medicine, Norfolk, Virginia 23507, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Intravaginal
Embryo Transfer
Endometrium / drug effects,  physiology
Fertilization in Vitro / methods*
Gels / administration & dosage
Oocyte Donation*
Pilot Projects
Pregnancy Rate
Progesterone / administration & dosage*,  analogs & derivatives
Prospective Studies
Reg. No./Substance:
0/Crinone; 0/Gels; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mechanisms of uterine specificity of vaginal progesterone.
Next Document:  Combined sciatic-femoral nerve block with 0.75% ropivacaine: effects of adding a systemically inacti...