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Vaginal bleeding in early pregnancy and circulating markers of thrombin generation.
MedLine Citation:
PMID:  22129041     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To determine if subjects experiencing acute vaginal bleeding in early pregnancy have increased plasma markers of thrombin generation compared to non-bleeding controls. Methods: Subjects with clinically apparent acute (within 24 hours of sample collection) vaginal bleeding between 6 and 20 weeks estimated gestational age and without known thrombophilias were enrolled, along with non-bleeding controls, and underwent collection of maternal plasma. Concentrations of thrombin-antithrombin (TAT) and fragment 1 + 2 (F1+2) were determined by enzyme linked immunosorbent assay. Differences between bleeding and non-bleeding subjects were assessed through linear regression with adjustment for gestational age. Results: 20 subjects with vaginal bleeding and 20 controls were included. Bleeding was significantly associated with increased concentrations of TAT (p=0.007) and F1+2 (p=0.044) when corrected for gestational age. Among bleeding subjects, there was no association between markers of thrombin generation and the subject's description of bleeding quantity, though higher concentrations were associated with a longer self-reported duration of bleeding. Conclusions: Clinically apparent vaginal bleeding in early pregnancy is associated with increased circulating maternal markers of thrombin generation. Thus, these maternal markers may have a future role in risk stratification.
Authors:
David N Hackney; Richard K Miller; Eva K Pressman; Charles W Francis; Hyagriv N Simhan
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-30
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, University of Rochester School of Medicine, Rochester New York.
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