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Vaginal Misoprostol vs Vaginal Misoprostol With Estradiol for Labor Induction: A Prospective Double Blind Study.
MedLine Citation:
PMID:  23372290     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare the safety and effectiveness of vaginal misoprostol with combined vaginal misoprostol and estradiol for induction of labor in unfavorable cervix.
METHOD: A prospective study was carried out from Jan 2008 to Jul 2008 on total of 90 women with unfavorable cervix (Bishop's score was <5) and gestation >36 weeks with clinical indication for induction of labor. They were randomly assigned to receive either vaginal misoprostol 25 μg alone or vaginal misoprostol 25 μg with vaginal estradiol 50 μg. Misoprostol alone was repeated every 3 h in both groups till ripening of cervix (Bishop's score was = 8) and establishment of active labor.
RESULTS: Main indications were post dated pregnancies (period of gestation >41 weeks) and pregnancy induced hypertension. Age, parity and mode of delivery were not significantly different. No significant difference was found in pre induction Bishop's score, fetal outcome and maternal complications. However, doses of misoprostol required for cervical ripening (p = 0.017), time required for cervical ripening (p = 0.042), time required for starting of active labor (p = 0.017) and time required for delivery in vaginal delivery cases (p = 0.047) were found significantly less in combined estradiol and misoprostol group.
CONCLUSION: Estradiol acts synergistically with misoprostol vaginally and significantly hastens the process of cervical ripening, initiation of active labor and vaginal delivery.
Authors:
Ellora Dasgupta; Gurneesh Singh
Publication Detail:
Type:  Journal Article     Date:  2012-04-20
Journal Detail:
Title:  Journal of obstetrics and gynaecology of India     Volume:  62     ISSN:  0971-9202     ISO Abbreviation:  J Obstet Gynaecol India     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2013-02-01     Completed Date:  2013-02-04     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0374763     Medline TA:  J Obstet Gynaecol India     Country:  India    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  -    
Affiliation:
Department of Obstetrics & Gynecology, NC Jindal Institute of Medical Sciences, Model Town, Hisar 125005 India.
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