Document Detail


Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells.
MedLine Citation:
PMID:  21976645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although implied by other models, proof that Langerhans cells (LCs) in the human vagina participate in dissemination of infectious human immunodeficiency virus type 1 (HIV-1) has been lacking. Here, we show that LCs migrate from HIV-1-exposed vaginal epithelia and pass infectious virus to CD4+ T cells without being productively infected themselves, and we point to a pathway that might enable HIV-1 to avoid degradation in vaginal LCs. Transport by migratory LCs to local lymphatics in a nonproductive but infectious form may aid HIV-1 in evasion of topical microbicides that target its intracellular productive life cycle.
Authors:
Lamar Ballweber; Barry Robinson; Allison Kreger; Michael Fialkow; Gretchen Lentz; M Juliana McElrath; Florian Hladik
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-10-05
Journal Detail:
Title:  Journal of virology     Volume:  85     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-22     Completed Date:  2012-01-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13443-7     Citation Subset:  IM    
Affiliation:
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., D3-100, Seattle, WA 98109-1024, USA.
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MeSH Terms
Descriptor/Qualifier:
CD4-Positive T-Lymphocytes / virology*
Cell Movement
Female
HIV Infections / transmission*,  virology
HIV-1 / growth & development*,  pathogenicity*
Humans
Langerhans Cells / virology*
Vagina / immunology*,  virology*
Grant Support
ID/Acronym/Agency:
R01HD51455/HD/NICHD NIH HHS; R37AI035605/AI/NIAID NIH HHS
Comments/Corrections

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