| Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells. | |
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MedLine Citation:
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PMID: 21976645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although implied by other models, proof that Langerhans cells (LCs) in the human vagina participate in dissemination of infectious human immunodeficiency virus type 1 (HIV-1) has been lacking. Here, we show that LCs migrate from HIV-1-exposed vaginal epithelia and pass infectious virus to CD4+ T cells without being productively infected themselves, and we point to a pathway that might enable HIV-1 to avoid degradation in vaginal LCs. Transport by migratory LCs to local lymphatics in a nonproductive but infectious form may aid HIV-1 in evasion of topical microbicides that target its intracellular productive life cycle. |
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Authors:
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Lamar Ballweber; Barry Robinson; Allison Kreger; Michael Fialkow; Gretchen Lentz; M Juliana McElrath; Florian Hladik |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-10-05 |
Journal Detail:
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Title: Journal of virology Volume: 85 ISSN: 1098-5514 ISO Abbreviation: J. Virol. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-22 Completed Date: 2012-01-23 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: United States |
Other Details:
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Languages: eng Pagination: 13443-7 Citation Subset: IM |
Affiliation:
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Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., D3-100, Seattle, WA 98109-1024, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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CD4-Positive T-Lymphocytes
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virology* Cell Movement Female HIV Infections / transmission*, virology HIV-1 / growth & development*, pathogenicity* Humans Langerhans Cells / virology* Vagina / immunology*, virology* |
| Grant Support | |
ID/Acronym/Agency:
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R01HD51455/HD/NICHD NIH HHS; R37AI035605/AI/NIAID NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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