| Vaginal (Crinone 8%) gel vs intramuscular progesterone in oil for luteal phase support in in vitro fertilization: a large prospective trial. | |
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MedLine Citation:
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PMID: 22188983 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the efficacy of intravaginal and IM P for luteal phase support in IVF cycles. DESIGN: Prospective trial. SETTING: Tertiary care private practice. PATIENT(S): Women 25-44 years old with infertility necessitating treatment with IVF. From April 1, 2008-April 1, 2009, 511 consecutive patients were enrolled; 474 completed participation, and 37 were excluded for no autologous ET (freeze all, donor recipients, failed fertilization/cleavage). There were no demographic differences between the two treatment groups. INTERVENTION(S): Luteal phase support using either Crinone or P in oil starting 2 days following oocyte retrieval. MAIN OUTCOME MEASURE(S): Pregnancy and delivery rates stratified by patient age. RESULT(S): Overall, patients who received vaginal P had higher pregnancy (70.9% vs 64.2%) and delivery (51.7% vs 45.4%) rates than did patients who received IM P. Patients <35 who received vaginal P had significantly higher delivery rates (65.7% vs 51.1%) than did patients who received IM P. There were no differences, regardless of age, in the rates of biochemical pregnancy, miscarriage, or ectopics. CONCLUSION(S): In younger patients undergoing IVF, support of the luteal phase with Crinone produces significantly higher pregnancy rates than does IM P. Crinone and IM P appear to be equally efficacious in the older patient. |
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Authors:
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Kaylen M Silverberg; Thomas C Vaughn; Lisa J Hansard; Natalie Z Burger; Tamara Minter |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-15 |
Journal Detail:
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Title: Fertility and sterility Volume: - ISSN: 1556-5653 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Texas Fertility Center and Austin IVF, Austin, Texas. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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