Document Detail

Vaginal (Crinone 8%) gel vs intramuscular progesterone in oil for luteal phase support in in vitro fertilization: a large prospective trial.
MedLine Citation:
PMID:  22188983     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To compare the efficacy of intravaginal and IM P for luteal phase support in IVF cycles. DESIGN: Prospective trial. SETTING: Tertiary care private practice. PATIENT(S): Women 25-44 years old with infertility necessitating treatment with IVF. From April 1, 2008-April 1, 2009, 511 consecutive patients were enrolled; 474 completed participation, and 37 were excluded for no autologous ET (freeze all, donor recipients, failed fertilization/cleavage). There were no demographic differences between the two treatment groups. INTERVENTION(S): Luteal phase support using either Crinone or P in oil starting 2 days following oocyte retrieval. MAIN OUTCOME MEASURE(S): Pregnancy and delivery rates stratified by patient age. RESULT(S): Overall, patients who received vaginal P had higher pregnancy (70.9% vs 64.2%) and delivery (51.7% vs 45.4%) rates than did patients who received IM P. Patients <35 who received vaginal P had significantly higher delivery rates (65.7% vs 51.1%) than did patients who received IM P. There were no differences, regardless of age, in the rates of biochemical pregnancy, miscarriage, or ectopics. CONCLUSION(S): In younger patients undergoing IVF, support of the luteal phase with Crinone produces significantly higher pregnancy rates than does IM P. Crinone and IM P appear to be equally efficacious in the older patient.
Kaylen M Silverberg; Thomas C Vaughn; Lisa J Hansard; Natalie Z Burger; Tamara Minter
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-15
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Texas Fertility Center and Austin IVF, Austin, Texas.
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