Document Detail

Vagally mediated volume-dependent modulation of inspiratory duration in the neonatal lamb.
MedLine Citation:
PMID:  8175536     Owner:  NLM     Status:  MEDLINE    
Inspiratory mechanical loads elicit a reflex volume-timing response in human infants and experimental animals. In adult animals, this reflex has been shown to be mediated by vagal afferents. It was hypothesized that the volume-related regulation of inspiratory duration would also be vagally mediated in the newborn. Single-breath graded inspiratory loads were presented to 4-day-old anesthetized neonatal lambs breathing through a facemask, after tracheostomy, and after bilateral cervical vagotomy. Inspired volume decreased and inspiratory duration (TI) increased with increasing load magnitude. The increase in TI was greater with facemask loads than with loads presented after tracheostomy for equivalent changes in inspired volume. The volume-related prolongation of TI after tracheostomy was abolished after cervical bilateral vagotomy. The results demonstrate that the volume-timing reflex in neonatal lambs after tracheostomy is mediated by vagal afferents. However, in the intact lamb, there is also a significant contribution to this reflex by upper airway afferents.
B Webb; A A Hutchison; P W Davenport
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  76     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-06-06     Completed Date:  1994-06-06     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  397-402     Citation Subset:  IM; S    
Department of Physiological Sciences, University of Florida, Gainesville 32610.
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MeSH Terms
Airway Resistance / physiology
Animals, Newborn / physiology*
Diaphragm / physiology
Electrodes, Implanted
Lung / anatomy & histology,  innervation,  physiology*
Lung Compliance / physiology
Neurons, Afferent / physiology
Respiratory Mechanics / physiology*
Vagus Nerve / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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