| Vagal stimulation for heart failure. | |
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MedLine Citation:
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PMID: 21099680 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: On the very solid background of experimental and clinical studies pointing to the cardiovascular risks associated with depressed vagal reflexes and supported by specific experiments in animal models of heart failure, we are witnessing a rapidly growing interest in the very untraditional approach to the management of heart failure represented by chronic vagal stimulation. RECENT FINDINGS: Additional studies have been performed using vagal stimulation in animal models of heart failure showing that benefit can occur even in the absence of heart rate changes. The first in-man studies of chronic vagal stimulation have been performed, first as a single center and then as a small multicenter study with favorable results in terms of feasibility, safety, and efficacy. SUMMARY: The initial observations with chronic vagal stimulation in man, though limited by very small numbers, are very encouraging and seem to open new paths, or perhaps avenues, for the management of symptomatic heart failure. This transition between experimental and clinical approaches represents an exciting example of translational research. |
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Authors:
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Peter J Schwartz |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in cardiology Volume: 26 ISSN: 1531-7080 ISO Abbreviation: Curr. Opin. Cardiol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2012-03-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608087 Medline TA: Curr Opin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 51-4 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Section of Cardiology, University of Pavia, Pavia, Italy. peter.schwartz@unipv.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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