Document Detail


Vagal and sinoaortic reflexes in postural control of circulation and renin release.
MedLine Citation:
PMID:  464105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anesthetized cats were subjected to two 10-min trials of head-up tilting spaced 60 min apart. Bilateral cervical vagotomy, performed after the first tilting episode, did not affect the hemodynamic response to the change in posture, but significantyly and markedly reduced the increase in renin release from the innervated kidney. After sinoaortic denervation a marked and sustained arterial hypotension occurred during tilting, and the postural increase in renin release, though still limited to the innervated kidney, was even greater. When pressure homeostasis to tilting was disturbed, the renin release response was seen to be independent of the vagi, as it occurred after combined vagotomy and sinoaortic denervation. Maintenance of arterial pressure during tilting is mainly due to sinoaortic reflexes, whereas vagal reflexes are mostly responsible for the postural increase in renin release. The vagally independent release of renin observed when the cardiovascular response to tilting is impaired, is probably due to a direct action of arterial hypotension on intrarenal receptors, an action occurring only in innervated kidneys.
Authors:
R A Dampney; A Stella; R Golin; A Zanchetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  237     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H146-52     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / innervation
Blood Pressure*
Carotid Sinus / innervation
Cats
Denervation
Female
Kidney / blood supply
Male
Posture*
Pressoreceptors / physiology*
Reflex / physiology*
Regional Blood Flow
Renin / blood*
Vagus Nerve / physiology
Chemical
Reg. No./Substance:
EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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