Document Detail


Vagal nerve stimulation induces intermittent hypocapnia.
MedLine Citation:
PMID:  14636333     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To study whether respiratory alteration caused by vagal nerve stimulation (VNS) can change end-tidal carbon dioxide (EtCO2) levels. METHODS: We performed polygraphic recordings including capnographic monitoring during daytime sleep on adults with VNS therapy. RESULTS: Ten of 13 patients showed VNS-induced alterations in the frequency or amplitude of respiration. Five patients had a consistent increase in respiratory rate with a simultaneous, consistent and significant decrease (p < 0.01; 5-22%) in EtCO2 during VNS. Three subjects showed occasional decreases in EtCO2 during VNS, and two showed no clearly detectable VNS-related EtCO2 changes. CONCLUSIONS: Our findings suggest that VNS may alter brain CO2 levels through changes in respiration. Because carbon dioxide (CO2) has potent effects on various brain functions, it is possible that these transient CO2 changes may have an effect on the state transitions between interictal and preictal states.
Authors:
Mark D Holmes; John W Miller; Juha Voipio; Kai Kaila; Sampsa Vanhatalo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  44     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-25     Completed Date:  2004-02-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1588-91     Citation Subset:  IM    
Affiliation:
Department of Neurology, Regional Epilepsy Center, University of Washington, Seattle, WA, U.S.A.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / physiopathology
Capnography
Electric Stimulation Therapy*
Electroencephalography
Epilepsies, Partial / therapy*
Epilepsy, Generalized / therapy*
Female
Humans
Hypocapnia / etiology*,  physiopathology
Male
Middle Aged
Polysomnography
Pulmonary Ventilation / physiology
Tidal Volume / physiology
Treatment Outcome
Vagus Nerve / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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