Document Detail

Vagal nerve stimulation in prevention and management of coronary heart disease.
MedLine Citation:
PMID:  21526047     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Coronary heart disease (CHD) that is due to atherosclerosis is associated with low-grade systemic inflammation. Congestive cardiac failure and arrhythmias that are responsible for mortality in CHD can be suppressed by appropriate vagal stimulation that is anti-inflammatory in nature. Acetylcholine, the principal vagal neurotransmitter, is a potent anti-inflammatory molecule. Polyunsaturated fatty acids (PUFAs) augment acetylcholine release, while acetylcholine can enhance the formation of prostacyclin, lipoxins, resolvins, protectins and maresins from PUFAs, which are anti-inflammatory and anti-arrhythmic molecules. Furthermore, plasma and tissue levels of PUFAs are low in those with CHD and atherosclerosis. Hence, vagal nerve stimulation is beneficial in the prevention of CHD and cardiac arrhythmias. Thus, measurement of catecholamines, acetylcholine, various PUFAs, and their products lipoxins, resolvins, protectins and maresins in the plasma and peripheral leukocytes, and vagal tone by heart rate variation could be useful in the prediction, prevention and management of CHD and cardiac arrhythmias.
Undurti N Das
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of cardiology     Volume:  3     ISSN:  1949-8462     ISO Abbreviation:  World J Cardiol     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-28     Completed Date:  2011-05-12     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101537090     Medline TA:  World J Cardiol     Country:  China    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  -    
Undurti N Das, UND Life Sciences, 13800 Fairhill Road, #321, Shaker Heights, OH 44120, United States.
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