| Vagal modulation of respiratory control during exercise. | |
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MedLine Citation:
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PMID: 1129547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vagal modulation of chemical control of ventilation during rest and exercise was studied in 15 anesthetized mongrel dogs. Arterial chemical stimuli--hypoxic, hypercapnic or a combination of both, increased ventilation by increasing both rate and depth of breathing during rest and exercise in the intact dogs. After bilateral vagotomy chemical drive increased ventilation mostly by depth and little by rate. The ventilatory response to the chemical drive, therefore, reached a plateau when tidal volume approached its maximal value ata relatively unchanged breath frequency. Muscular exercise, however, largely restored frequency response in the vagotomized animals. Since the rate response to chemical stimuli but not to exercise was impaired by vagotomy, we concluded that hyperpnea of exercise could occur through a mechanism not shared by the chemical control of ventilation. The relationship between tidal volume and breath cycle during chemical stimulation was modulated by the volume related vagal reflex. During exercise, another mechanism, presumably bulbo-pontine, is activated to influence the relationship independent of the lung volume. |
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Authors:
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S Lahiri; S S Mei; F F Kao |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Respiration physiology Volume: 23 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-07-14 Completed Date: 1975-07-14 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 133-46 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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physiopathology Animals Anoxia / physiopathology Carotid Sinus / innervation Denervation Dogs Hypercapnia / physiopathology Male Muscles / physiopathology Partial Pressure Physical Exertion* Respiration* Spirometry Tidal Volume Vagotomy Vagus Nerve / physiology* |
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