Document Detail

Vagal influences on respiratory mechanics, pressures, and control in rats.
MedLine Citation:
PMID:  3175356     Owner:  NLM     Status:  MEDLINE    
In eight spontaneously breathing anesthetized rats airflow, volume, and tracheal pressure were measured. The passive and active mechanical properties of the respiratory system, the shape of the tracheal occlusion pressure wave (Potr), the decay of inspiratory muscle pressure during expiration, and parameters related to the control of breathing were computed both before and after bilateral cervical vagotomy. Pre- and post-vagotomy values of passive elastance, resistance, and time constant were similar. Active mechanics disclosed an increase of elastance and a decrease in resistance and in the time constant after vagotomy. The time course of Potr showed a downward concavity and was not modified by vagotomy in the range of control inspiratory times, whereas the shape of inspiratory muscle pressure decay during expiration was changed. The present data help to explain why after vagotomy the load-compensatory mechanisms are less effective.
M P Caldeira; P H Saldiva; W A Zin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  73     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-10-31     Completed Date:  1988-10-31     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  43-53     Citation Subset:  IM; S    
Laboratório de Poluição Atmosférica Experimental, Faculdade de Medicina, Universidade de São Paulo, Brazil.
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MeSH Terms
Rats, Inbred Strains
Time Factors
Trachea / physiology
Vagus Nerve / physiology*

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