Document Detail


Vagal feedback is essential for breathing in unanesthetized ground squirrels.
MedLine Citation:
PMID:  11282387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The roles of vagal afferent feedback in terminating inspiration and modulating breathing pattern and ventilatory responses to hypoxia and hypercapnia were assessed in the golden-mantled ground squirrel, Spermophilus lateralis, during wakefulness and urethane anesthesia. Hypoxia increased ventilation primarily through increases in breathing frequency (f(R)) while hypercapnia increased ventilation primarily through increases in tidal volume (V(T)) in both anesthetized and unanesthetized animals. Vagotomy resulted in an increase in tidal volume, a decrease in breathing frequency and ventilation, and depressed ventilatory responses to both hypoxia and hypercapnia in anesthetized animals. In unanesthetized animals vagotomy produced a transient 'gasp-like' breathing pattern that rapidly progressed to a non-obstructive central apnea. These data indicate that vagal feedback shapes ventilation on a breath-by-breath basis during anesthesia and is essential for ventilation in unanesthetized animals. The mechanisms that transform the influences of vagal input on breathing between anesthetized and unanesthetized states remain unclear. Changes in breathing pattern induced by the removal of vagal feedback compromise chemoreflexes.
Authors:
M B Harris; W K Milsom
Related Documents :
19407057 - Consort hypersensitivity pneumonitis.
8887597 - Role of hypoxemia and pulmonary mechanics in exercise limitation in interstitial lung d...
9232687 - Influence of thoracoabdominal pattern of breathing on respiratory resistance.
11880227 - Response to carbon dioxide by the infective larvae of three species of parasitic nemato...
2925967 - Effects of running or weight lifting on self-concept in clinically depressed women.
23337207 - Exercise intolerance in chronic heart failure.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  125     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-03     Completed Date:  2001-06-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  199-212     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, BC, V6T 1Z4, Canada. michael.b.harris@dartmouth.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acute Disease
Afferent Pathways / physiology
Anesthesia
Animals
Anoxia / physiopathology
Chronic Disease
Feedback
Female
Hypercapnia / physiopathology
Male
Respiratory Mechanics / physiology*
Sciuridae / physiology*
Vagotomy
Vagus Nerve / physiology*
Wakefulness / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The influence of NMDA receptor-mediated processes on breathing pattern in ground squirrels.
Next Document:  Alpha2 adrenergic receptors and the central control of breathing in the cane toad, Bufo marinus.