Document Detail


Vagal afferent input determines the volume dependence of rat esophageal motility patterns.
MedLine Citation:
PMID:  11408254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The volume dependence of balloon distension-evoked esophageal rhythmic motor responses and their neural correlates was investigated in 72 urethane-anesthetized rats. With increasing balloon volume (75--200 microl), distal esophageal rhythmic contractions decreased in rate and became tonic in the range of 150--250 microl. This change in motor pattern involved only the striated musculature of the esophageal body and persisted after acute transection of the spinal cord at C(2). Impulse frequency in single vagal afferents of the distal esophagus increased with intraluminal pressure over the entire range of balloon volumes tested (50--300 microl). Distension-responsive neurons in the nucleus tractus solitarii showed rhythmic burst activity (type I), tonic excitation (type II), or inhibition followed by off bursts (type III). Increasing strength of stimulation changed type I responses to nonrhythmic but intensified type II and III responses. We conclude that load-dependent changes in distal esophagus motility pattern are encoded by vagal afferents alone and do not involve a spinal afferent input even at near-noxious stimulus strengths.
Authors:
H Dong; C W Loomis; D Bieger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  281     ISSN:  0193-1857     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-15     Completed Date:  2001-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  G44-53     Citation Subset:  IM    
Affiliation:
Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3V6.
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MeSH Terms
Descriptor/Qualifier:
Animals
Balloon Dilatation
Blood Pressure / physiology
Electrophysiology
Esophagus / innervation*,  physiology*
Interneurons / physiology
Male
Muscle, Skeletal / innervation,  physiology
Muscle, Smooth / innervation,  physiology
Pain / physiopathology
Rats
Rats, Sprague-Dawley
Solitary Nucleus / cytology,  physiology
Spinal Cord / cytology,  physiology
Vagus Nerve / cytology,  physiology*
Visceral Afferents / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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