Document Detail


Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass.
MedLine Citation:
PMID:  20119735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of this study was to evaluate whether gastric bypass with or without vagal preservation resulted in a different outcome.
METHODS: Body weight, food intake and postprandial peptide YY (PYY) and glucagon-like peptide (GLP-1) levels were compared between gastric bypass (n = 55) and sham-operated rats (n = 27) in three groups. In group 1 (n = 17), the vagal nerve was not preserved, while in group 2 the vagal nerve was preserved during gastric bypass (n = 10). In group 3, gastric bypass rats (n = 28) were randomised for either one of the two techniques.
RESULTS: Rats in which the vagal nerve was preserved during gastric bypass showed a lower body weight (p < 0.001) and reduced food intake (p < 0.001) compared to rats in which the vagal nerve was not preserved during the gastric bypass operation. Levels of PYY and GLP-1 were significantly increased after gastric bypass compared to sham-operated controls (p < 0.05), but there was no difference between gastric bypass rats with and without vagal preservation. Differences in food intake and body weight were not related to the size of the gastro-jejunostomy in gastric bypass rats. There were no signs of malabsorption or inflammation after gastric bypass.
CONCLUSION: We propose that the vagal nerve should be preserved during the gastric bypass operation as this might play an important role for the mechanisms that induce weight loss and reduce food intake in rats. In contrast, the gastro-jejunal stoma size was found to be of minor relevance.
Authors:
Marco Bueter; Christian Löwenstein; Hutan Ashrafian; Jacquelien Hillebrand; Stephen R Bloom; Torsten Olbers; Thomas Lutz; Carel W le Roux
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-30
Journal Detail:
Title:  Obesity surgery     Volume:  20     ISSN:  1708-0428     ISO Abbreviation:  Obes Surg     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-08     Completed Date:  2011-02-02     Revised Date:  2013-07-25    
Medline Journal Info:
Nlm Unique ID:  9106714     Medline TA:  Obes Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  616-22     Citation Subset:  IM    
Affiliation:
Imperial Weight Centre, Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, Du Cane Road, London W12 0NN, UK. m.bueter@imperial.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Gastric Bypass / methods*
Gastrostomy
Glucagon-Like Peptide 1 / analysis
Jejunostomy
Male
Obesity, Morbid / metabolism,  surgery*
Peptide YY / analysis
Postprandial Period
Random Allocation
Rats
Rats, Wistar
Treatment Outcome
Vagus Nerve / surgery*
Weight Loss*
Grant Support
ID/Acronym/Agency:
083662//Wellcome Trust
Chemical
Reg. No./Substance:
106388-42-5/Peptide YY; 89750-14-1/Glucagon-Like Peptide 1
Comments/Corrections

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