| Vagal innervation of the hepatic portal vein and liver is not necessary for Roux-en-Y gastric bypass surgery-induced hypophagia, weight loss, and hypermetabolism. | |
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MedLine Citation:
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PMID: 22202582 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the role of the common hepatic branch of the abdominal vagus on the beneficial effects of Roux-en-Y gastric bypass (RYGB) on weight loss, food intake, food choice, and energy expenditure in a rat model. BACKGROUND: Although changes in gut hormone patterns are the leading candidates in RYGB's effects on appetite, weight loss, and reversal of diabetes, a potential role for afferent signaling through the vagal hepatic branch potentially sensing glucose levels in the hepatic portal vein has recently been suggested in a mouse model of RYGB. METHODS: Male Sprague-Dawley rats underwent either RYGB alone (RYGB; n = 7), RYGB + common hepatic branch vagotomy (RYGB + HV; n = 6), or sham procedure (sham; n = 9). Body weight, body composition, meal patterns, food choice, energy expenditure, and fecal energy loss were monitored up to 3 months after intervention. RESULTS: Both RYGB and RYGB + HV significantly reduced body weight, adiposity, meal size, and fat preference, and increased satiety, energy expenditure, and respiratory exchange rate compared with sham procedure, and there were no significant differences in these effects between RYGB and RYGB + HV rats. CONCLUSIONS: Integrity of vagal nerve supply to the liver, hepatic portal vein, and the proximal duodenum provided by the common hepatic branch is not necessary for RYGB to reduce food intake and body weight or increase energy expenditure. Specifically, it is unlikely that a hepatic portal vein glucose sensor signaling RYGB-induced increased intestinal gluconeogenesis to the brain depends on vagal afferent fibers. |
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Authors:
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Andrew C Shin; Huiyuan Zheng; Hans-Rudolf Berthoud |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Annals of surgery Volume: 255 ISSN: 1528-1140 ISO Abbreviation: Ann. Surg. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-16 Completed Date: 2012-03-20 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: United States |
Other Details:
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Languages: eng Pagination: 294-301 Citation Subset: AIM; IM |
Affiliation:
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Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Regulation / physiology* Disease Models, Animal Energy Metabolism / physiology* Gastric Bypass* Hepatic Veins / innervation Liver / blood supply, innervation* Male Obesity, Morbid / surgery* Portal Vein / innervation* Random Allocation Rats Rats, Sprague-Dawley Treatment Outcome Vagotomy Vagus Nerve / physiology*, surgery Weight Loss / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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DK 071082/DK/NIDDK NIH HHS; DK 47348/DK/NIDDK NIH HHS; R01 DK047348/DK/NIDDK NIH HHS; R01 DK047348-17/DK/NIDDK NIH HHS; R01 DK071082/DK/NIDDK NIH HHS; R01 DK071082-04/DK/NIDDK NIH HHS |
| Comments/Corrections | |
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