Document Detail


Vagal innervation of the hepatic portal vein and liver is not necessary for Roux-en-Y gastric bypass surgery-induced hypophagia, weight loss, and hypermetabolism.
MedLine Citation:
PMID:  22202582     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the role of the common hepatic branch of the abdominal vagus on the beneficial effects of Roux-en-Y gastric bypass (RYGB) on weight loss, food intake, food choice, and energy expenditure in a rat model.
BACKGROUND: Although changes in gut hormone patterns are the leading candidates in RYGB's effects on appetite, weight loss, and reversal of diabetes, a potential role for afferent signaling through the vagal hepatic branch potentially sensing glucose levels in the hepatic portal vein has recently been suggested in a mouse model of RYGB.
METHODS: Male Sprague-Dawley rats underwent either RYGB alone (RYGB; n = 7), RYGB + common hepatic branch vagotomy (RYGB + HV; n = 6), or sham procedure (sham; n = 9). Body weight, body composition, meal patterns, food choice, energy expenditure, and fecal energy loss were monitored up to 3 months after intervention.
RESULTS: Both RYGB and RYGB + HV significantly reduced body weight, adiposity, meal size, and fat preference, and increased satiety, energy expenditure, and respiratory exchange rate compared with sham procedure, and there were no significant differences in these effects between RYGB and RYGB + HV rats.
CONCLUSIONS: Integrity of vagal nerve supply to the liver, hepatic portal vein, and the proximal duodenum provided by the common hepatic branch is not necessary for RYGB to reduce food intake and body weight or increase energy expenditure. Specifically, it is unlikely that a hepatic portal vein glucose sensor signaling RYGB-induced increased intestinal gluconeogenesis to the brain depends on vagal afferent fibers.
Authors:
Andrew C Shin; Huiyuan Zheng; Hans-Rudolf Berthoud
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Annals of surgery     Volume:  255     ISSN:  1528-1140     ISO Abbreviation:  Ann. Surg.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-03-20     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  294-301     Citation Subset:  AIM; IM    
Affiliation:
Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Regulation / physiology*
Disease Models, Animal
Energy Metabolism / physiology*
Gastric Bypass*
Hepatic Veins / innervation
Liver / blood supply,  innervation*
Male
Obesity, Morbid / surgery*
Portal Vein / innervation*
Random Allocation
Rats
Rats, Sprague-Dawley
Treatment Outcome
Vagotomy
Vagus Nerve / physiology*,  surgery
Weight Loss / physiology*
Grant Support
ID/Acronym/Agency:
DK 071082/DK/NIDDK NIH HHS; DK 47348/DK/NIDDK NIH HHS; R01 DK047348/DK/NIDDK NIH HHS; R01 DK047348-17/DK/NIDDK NIH HHS; R01 DK071082/DK/NIDDK NIH HHS; R01 DK071082-04/DK/NIDDK NIH HHS
Comments/Corrections

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