| Vacuum-assisted minimally invasive biopsy of soft-tissue tumors. | |
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MedLine Citation:
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PMID: 22257995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although exact histological characterization of soft-tissue tumors is essential for determining the appropriate therapy, the quality of the histological assessment is often limited by the size of the tissue samples. Incisional biopsy and core needle biopsy have been the most effective techniques for obtaining tissue samples from soft-tissue tumors. This study was performed to investigate whether vacuum-assisted biopsy can serve as a new diagnostic tool for soft-tissue neoplasms. METHODS: This retrospective study compared the characterization made with use of vacuum-assisted biopsy of soft-tissue tumors in seventy-five patients between 2004 and 2006 and the characterization made with use of incisional biopsy of tumors in a comparison group of seventy-four patients between 2000 and 2005 with the final characterization made after radical tumor excision. All vacuum-assisted and incisional biopsies were performed by the same experienced surgeons and evaluated by the same experienced pathologists at a single tumor center. The sensitivity, specificity, positive and negative predictive values, and accuracy of the preliminary characterization made with use of each method were calculated on the basis of the final characterization made after excision. RESULTS: The vacuum-assisted biopsy procedure was performed successfully in seventy-four (99%) of the seventy-five patients. The accuracy of vacuum-assisted biopsy (96%) was comparable with that of incisional biopsy (99%). Vacuum-assisted biopsy correctly characterized the tumor as benign or malignant in 96% (95% confidence interval [CI], 92% to 100%) of the seventy-five patients compared with 99% (95% CI, 96% to 100%) of the seventy-four patients who underwent incisional biopsy. Vacuum-assisted biopsy correctly characterized the tumor diagnosis in 95% (95% CI, 90% to 100%) of the patients compared with 95% (95% CI, 89% to 100%) for incisional biopsy. Vacuum-assisted biopsy correctly characterized the tumor grade in 89% (95% CI, 82% to 96%) of the patients compared with 88% (95% CI, 80% to 95%) for incisional biopsy. The sensitivity of vacuum-assisted biopsy was 93% (95% CI, 71% to 100%), the specificity and the positive predictive value were both 100%, and the negative predictive value was 91% (95% CI, 85% to 98%). The overall accuracy of vacuum-assisted biopsy was 96% (95% CI, 92% to 100%). CONCLUSIONS: Vacuum-assisted biopsy appears to be safe and provides a new tool for the diagnosis of soft-tissue tumors. One advantage of vacuum-assisted biopsy is that it can be performed with use of local anesthesia in an outpatient setting. |
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Authors:
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Zarah Mohr; Christoph Hirche; Torsten Klein; Sören Kneif; Michael Hünerbein |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of bone and joint surgery. American volume Volume: 94 ISSN: 1535-1386 ISO Abbreviation: J Bone Joint Surg Am Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-19 Completed Date: 2012-03-06 Revised Date: 2012-04-11 |
Medline Journal Info:
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Nlm Unique ID: 0014030 Medline TA: J Bone Joint Surg Am Country: United States |
Other Details:
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Languages: eng Pagination: 103-9 Citation Subset: AIM; IM |
Affiliation:
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Department of General Surgery and Surgical Oncology, HELIOS Hospital Berlin-Buch, Berlin, Germany. zarahmohr@googlemail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Biopsy / methods Biopsy, Needle / instrumentation, methods* Child Female Humans Male Middle Aged Predictive Value of Tests Retrospective Studies Sensitivity and Specificity Soft Tissue Neoplasms / pathology* Surgical Procedures, Minimally Invasive / instrumentation, methods Vacuum Young Adult |
| Comments/Corrections | |
Comment In:
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J Bone Joint Surg Am. 2012 Jan 18;94(2):e11
[PMID:
22258008
]
Orthopedics. 2012 Mar;35(3):224-5 [PMID: 22385600 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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