| Vaccinia virus inhibits T cell receptor-dependent responses by human gammadelta T cells. | |
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MedLine Citation:
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PMID: 17152007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vaccinia virus (VV) is an effective vaccine and vector but has evolved multiple mechanisms for evading host immunity. We characterized the interactions of VV (TianTan and New York City Board of Health strains) with human gammadelta T cells because of the role they play in immune control of this virus. Exposure to VV failed to trigger proliferative responses in gammadelta T cells from unprimed individuals, but it was an unexpected finding that VV blocked responses to model antigens by the Vgamma2Vdelta2 T cell subset. Infectious or ultraviolet light-inactivated VV inhibited proliferative Vgamma2Vdelta2 T cell responses to phosphoantigens and tumor cells, prevented cytolysis of Daudi B cells, and reduced cytokine production. Inhibiting Vgamma2Vdelta2 T cells may be a mechanism for evading host immunity and increasing VV virulence. Increased VV replication or expression in the absence of gammadelta T cell responses might contribute to its potency as a vaccine against poxvirus and recombinant antigens. |
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Authors:
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Haishan Li; Carl O Deetz; Juan Carlos Zapata; Cristiana Cairo; Andrew M Hebbeler; Nadia Propp; Maria S Salvato; Yiming Shao; C David Pauza |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-11-20 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 195 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-07 Completed Date: 2007-02-15 Revised Date: 2011-03-17 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 37-45 Citation Subset: AIM; IM |
Affiliation:
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Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Leukocytes, Mononuclear Receptors, Antigen, T-Cell, gamma-delta / biosynthesis, genetics, physiology* Receptors, Immunologic / genetics T-Lymphocyte Subsets / immunology*, virology T-Lymphocytes, Cytotoxic / drug effects, immunology* Vaccinia / genetics, immunology, virology Vaccinia virus / immunology*, pathogenicity |
| Grant Support | |
ID/Acronym/Agency:
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AI51212/AI/NIAID NIH HHS; CA 113621/CA/NCI NIH HHS; R01 AI038491-04/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Antigen, T-Cell, gamma-delta; 0/Receptors, Immunologic |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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