Document Detail


Vaccinia virus complement control protein modulates inflammation following spinal cord injury.
MedLine Citation:
PMID:  15033786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The vaccinia virus complement control protein (VCP) possesses multiple modulatory functions. Functioning as a complement inhibitory protein, VCP reduces production of proinflammatory chemotactic factors produced during complement activation. Additionally, VCP binds heparin and heparan sulfate proteoglycans, resulting in added functions shown to block monocyte chemotaxis in vitro. Using an in vivo spinal cord contusive injury model in rats, the inflammation-modulating abilities of VCP were evaluated. The results of both myeloperoxidase assaying and H&E stained section counts of spinal tissue reveal that neutrophil infiltration to the area of the lesion was reduced in animals that received VCP as compared to saline-injected controls.
Authors:
D N Reynolds; S A Smith; Y-P Zhang; D K Lahiri; D J Morassutti; C B Shields; G J Kotwal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1010     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-03-22     Completed Date:  2004-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  534-9     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Inflammation / etiology,  pathology,  therapy*
Injections, Spinal
Peroxidase / metabolism
Rats
Rats, Sprague-Dawley
Spinal Cord Injuries / pathology,  physiopathology*,  therapy*
Viral Proteins / administration & dosage,  physiology*
Chemical
Reg. No./Substance:
0/Viral Proteins; 0/complement-control protein, Vaccinia virus; EC 1.11.1.7/Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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