| Vaccinia virus complement control protein modulates inflammation following spinal cord injury. | |
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MedLine Citation:
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PMID: 15033786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The vaccinia virus complement control protein (VCP) possesses multiple modulatory functions. Functioning as a complement inhibitory protein, VCP reduces production of proinflammatory chemotactic factors produced during complement activation. Additionally, VCP binds heparin and heparan sulfate proteoglycans, resulting in added functions shown to block monocyte chemotaxis in vitro. Using an in vivo spinal cord contusive injury model in rats, the inflammation-modulating abilities of VCP were evaluated. The results of both myeloperoxidase assaying and H&E stained section counts of spinal tissue reveal that neutrophil infiltration to the area of the lesion was reduced in animals that received VCP as compared to saline-injected controls. |
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Authors:
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D N Reynolds; S A Smith; Y-P Zhang; D K Lahiri; D J Morassutti; C B Shields; G J Kotwal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1010 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2004-03-22 Completed Date: 2004-06-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 534-9 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Inflammation / etiology, pathology, therapy* Injections, Spinal Peroxidase / metabolism Rats Rats, Sprague-Dawley Spinal Cord Injuries / pathology, physiopathology*, therapy* Viral Proteins / administration & dosage, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Viral Proteins; 0/complement-control protein, Vaccinia virus; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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