| Vaccine-related HPV genotypes in women with and without cervical cancer in Mozambique: burden and potential for prevention. | |
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MedLine Citation:
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PMID: 18076064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Knowledge about the burden of Human Papillomavirus (HPV) infections in Sub-Saharan Africa is very limited. We collected cervical samples from 262 women from the general population and 241 tumor samples from women with invasive cervical cancer in Mozambique and tested them for HPV genotyping by the SPF(10)-LiPA(25) PCR system. Among the 195 women without cervical abnormalities by cytology HPV prevalence was 75.9%. In this group of women, the most frequently identified HPV types among HPV-positive women were in descending order of frequency: HPV51 (23.6%), HPV35 (19.6%), HPV18 (14.2%), HPV31 (13.5%) and HPV52 (12.8%). In women with cervical cancer HPV DNA detection was 100%. The type-specific distribution of the most frequent types in descending order of frequency was: HPV16 (47.0%), HPV18 (31.3%), HPV51 (14.8%), HPV52 (14.3%), HPV45 (12.6%), HPV35 (10.4%), HPV33 (4.8%) and HPV31 (2.6%). HPVs 16/18 and HPVs 16/18/31/45 were detected in 71.7% and 80.9% of cervical cancer tissue, respectively. While HPVs 51 and 35 were the two most common types in cytologically normal women in Mozambique, HPVs 16 and 18 remained the two most frequently identified types in cervical cancer. The introduction of an efficacious HPV 16/18 vaccine could potentially prevent the occurrence of 72% of cervical cancer cases and up to 81% of the cases if full cross-protection against HPVs 31 and 45 is assumed. |
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Authors:
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Xavier Castellsagué; Joellen Klaustermeier; Carla Carrilho; Ginesa Albero; Jahit Sacarlal; Wim Quint; Bernhard Kleter; Belen Lloveras; Mamudo Rafik Ismail; Silvia de Sanjosé; F Xavier Bosch; Pedro Alonso; Clara Menéndez |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 122 ISSN: 1097-0215 ISO Abbreviation: Int. J. Cancer Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-02-25 Completed Date: 2008-03-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1901-4 Citation Subset: IM |
Affiliation:
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IDIBELL, Institut Català d'Oncologia (ICO), L'Hospitalet de Llobregat, Barcelona, Spain. xcastellsague@iconcologia.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alphapapillomavirus / genetics, immunology, isolation & purification* Cost of Illness* DNA, Viral / isolation & purification Female Genotype Human papillomavirus 16 / isolation & purification Human papillomavirus 18 / isolation & purification Humans Middle Aged Mozambique / epidemiology Papillomavirus Infections / complications*, virology Papillomavirus Vaccines / administration & dosage* Primary Prevention / methods Tumor Virus Infections / complications*, virology Uterine Cervical Neoplasms / epidemiology*, genetics, immunology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 0/Papillomavirus Vaccines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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