Document Detail

Vaccination with Trichinella spirallis antigens increases CD8+ peripheral T cells and enhances the Th2 immune response in Leishmania infantum challenged mice.
MedLine Citation:
PMID:  19309564     Owner:  NLM     Status:  MEDLINE    
In this study we investigate the effect of Trichinella spiralis vaccination on immune responses elicited in BALB/c mice challenged subcutaneously with 0.5 x 10 6 of Leishmania infantum promastigotes. Secretion of specific anti-L. infantum antibodies and changes in the number of CD4+, CD8+ T cell and CD19+ B cells in the peripheral blood were tested for the evaluation of immune responses. Immunization with low amounts of T. spiralis antigens induced depression in anti-Leishmania specific antibodies of the IgG1 isotype, while no changes in the number of CD4+ and CD8+ T cell subpopulations or CD19+ B cells were observed. In contrast, high amounts of T. spiralis antigens induced an enhancement in anti-Leishmania specific antibodies of total IgG and IgG1 isotype, increase of CD8+ T cell number and activation of CD19+ B cells, indicated by the co-expression of CD69 marker. Our results suggest that immunization with a certain dose of T. spiralis antigens in experimentally challenged mice with L. infantum leads to an increase of peripheral CD8+ T cells which are responsible for the control of L. infantum infection, although a simultaneous enhancement in Th2-type of immune response is also observed.
M Daoudaki; A Diakou; S Frydas; I Fouzas; E Karagouni; N Vavatsi; S Haralabidis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  22     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2009 Jan-Mar
Date Detail:
Created Date:  2009-03-24     Completed Date:  2009-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  169-74     Citation Subset:  IM    
Department of Biological Chemistry, School of Medicine, Aristotle University, Thessaloniki, Greece.
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MeSH Terms
Antibodies, Protozoan / blood
Antigens, Helminth / immunology*
CD8-Positive T-Lymphocytes / immunology*
Immunoglobulin G / blood
Leishmania infantum / immunology*
Leishmaniasis, Visceral / immunology*
Mice, Inbred BALB C
Th2 Cells / immunology*
Trichinella spiralis / immunology*
Reg. No./Substance:
0/Antibodies, Protozoan; 0/Antigens, Helminth; 0/Immunoglobulin G

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