| Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells. | |
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MedLine Citation:
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PMID: 11342327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no side effects. Furthermore, cryoglobulin-specific proliferative responses were observed after the vaccination. As there was a recurrence of acrocyanosis after the final vaccination, vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia. |
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Authors:
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M Maeda; S Inaba; A Nomura; Y Tokunaga; Y Sugio; Y Itoh; T Iino; T Otsuka; S Okamura; Y Niho |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 39 ISSN: 1042-8194 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-05-08 Completed Date: 2001-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: Switzerland |
Other Details:
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Languages: eng Pagination: 441-6 Citation Subset: IM |
Affiliation:
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Blood Transfusion Service, Kyushu University Hospital Fukuoka, Japan. maedacc@cancer.med.kyushu-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens Clone Cells / pathology Cryoglobulinemia / pathology, therapy* Cryoglobulins / immunology Dendritic Cells / immunology, transplantation* Humans Immunotherapy, Adoptive / methods* Lymphocyte Culture Test, Mixed Male Middle Aged Vaccination |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Cryoglobulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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