Document Detail

Vaccination of rabbits against Entamoeba histolytica with aqueous suspensions of trehalose-dimycolate as the adjuvant.
MedLine Citation:
PMID:  2860068     Owner:  NLM     Status:  MEDLINE    
Rabbits were immunized with soluble Entamoeba histolytica antigen with an aqueous suspension of trehalose-6,6'-dimycolate used as the adjuvant. Induction of protective immunity in the immunized animals was demonstrated by enhanced humoral and cell-mediated immune responses and 100% survival after challenge. Administration of soluble antigen only failed to induce a similar degree of protective immunity. Trehalose-6,6'-dimycolate alone produced only a slight increase in nonspecific resistance.
A Sharma; A Haq; S Ahmad; E Lederer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Infection and immunity     Volume:  48     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-10     Completed Date:  1985-07-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  634-7     Citation Subset:  IM    
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MeSH Terms
Adjuvants, Immunologic / pharmacology*
Antibody Formation / drug effects
Antigens, Protozoan / immunology*
Cord Factors / pharmacology*
Entamoeba histolytica / immunology*
Entamoebiasis / immunology
Glycolipids / pharmacology*
Immunity, Cellular / drug effects
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antigens, Protozoan; 0/Cord Factors; 0/Glycolipids; 0/Suspensions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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