Document Detail


Vaccination against drug resistance in HIV infection.
MedLine Citation:
PMID:  18251699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HIV-1 resistance to currently employed antiretroviral drugs and drug-associated adverse reactions and toxicity point to a need for additional measures to control HIV-1 replication in HIV-infected patients. The immune system of HIV-infected individuals mount an immune response against the regions harboring drug-resistance mutations, sometimes stronger than that against the parental wild-type sequences. A potent cross-reactive immune response against drug-resistant pol proteins can suppress the replication of drug-escaping HIV. This suggests the possibility for a vaccination against existing and anticipated drug-resistant HIV variants. If successful, therapeutic vaccines against drug resistance would ease the therapeutic modalities and limit the spread of drug-resistant HIV. A better understanding of the complex interactions between patterns of drug-resistance mutations, immune responses against these mutations and their antigen presentation by particular human lymphocyte antigen alleles could help to tailor these vaccines after new drugs/new mutations. In this review, we describe the developments in the field of immunization against mutations conferring drug resistance and evaluate their prospects for human vaccination.
Authors:
Andreas Boberg; Maria Isaguliants
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert review of vaccines     Volume:  7     ISSN:  1744-8395     ISO Abbreviation:  Expert Rev Vaccines     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-06     Completed Date:  2008-08-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101155475     Medline TA:  Expert Rev Vaccines     Country:  England    
Other Details:
Languages:  eng     Pagination:  131-45     Citation Subset:  IM    
Affiliation:
Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden. andreas.boberg@smi.ki.se
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MeSH Terms
Descriptor/Qualifier:
AIDS Vaccines / administration & dosage,  therapeutic use*
Animals
Anti-HIV Agents / therapeutic use
Cross Reactions
Drug Administration Schedule
Drug Resistance, Viral* / genetics
HIV / genetics
HIV Infections / drug therapy,  immunology,  therapy*,  virology
Humans
Mice
Mutation
Chemical
Reg. No./Substance:
0/AIDS Vaccines; 0/Anti-HIV Agents

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