| Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats. | |
| | |
MedLine Citation:
|
PMID: 22254015 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean control (Ctl), obese Ctl rats had higher serum haptoglobin and impaired T-cell-stimulated cytokine responses. VA and EA diets improved T-cell-stimulated cytokine production; but, only VA normalized serum haptoglobin. However, EA- and VA-fed rats had enhanced LPS-stimulated cytokine responses. The changes elicited by VA were likely due changes in essential fatty acid composition in PL; whereas EA-induced changes may due to direct incorporation into membrane PL. |
| | |
Authors:
|
Megan R Ruth; Ye Wang; Howe-Ming Yu; Susan Goruk; Martin J Reaney; Spencer D Proctor; Donna F Vine; Catherine J Field |
Related Documents
:
|
16390185 - Residue formations of phosphorus hydride polymers and phosphorus oxyacids during phosph... 15457435 - Removal of the side-chain glucose groups from schizophyllan improves the thermal stabil... 5432705 - Catalytic activities of thermally prepared poly-alpha-amino acids: effect of aging. 19914585 - Rapid monomerization of poly(butylene succinate)-co-(butylene adipate) by leptothrix sp. 6836005 - Structure activity correlation for diuretic furosemide congeners. 18285335 - Identification of the interaction site within acyl-coa:cholesterol acyltransferase 2 fo... |
Publication Detail:
|
Type: Journal Article Date: 2010-02-11 |
Journal Detail:
|
Title: Nutrients Volume: 2 ISSN: 2072-6643 ISO Abbreviation: Nutrients Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2012-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101521595 Medline TA: Nutrients Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 181-97 Citation Subset: - |
Affiliation:
|
Boston University School of Medicine, 72 East Concord Street, Robinson 4400, Boston, MA, 02118, USA; Email: mruth@bu.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Production of Hesperetin Glycosides by Xanthomonas campestris and Cyclodextrin Glucanotransferase an...
Next Document: Do pregnant women and those at risk of developing post-natal depression consume lower amounts of lon...