Document Detail

VAB-8, UNC-73 and MIG-2 regulate axon polarity and cell migration functions of UNC-40 in C. elegans.
MedLine Citation:
PMID:  17237777     Owner:  NLM     Status:  MEDLINE    
One of the most intriguing features of axons is their ability to pioneer precise paths to their targets. How guidance-cue information is interpreted and integrated to form intricate neuronal networks has not been fully deciphered. Using Caenorhabditis elegans, we show that highly conserved receptors that guide pioneer axons along the dorsoventral axis, such as UNC-40 and SAX-3 (receptors for UNC-6 and SLT-1 guidance cues, respectively), can be co-opted to affect axon and cell migrations along the anterior-posterior axis. We further identify the kinesin-related VAB-8 protein as an upstream regulator of UNC-40, illuminating VAB-8's mechanism of action in determining the polarity of cell and axon migration. Finally, we show that UNC-73 and its target MIG-2 function with VAB-8 as upstream regulators of UNC-40 and that MIG-2 activity specifies UNC-40 subcellular localization. These data are indicative of previously unidentified regulatory roles for VAB-8 and small GTPases, which act together to regulate guidance receptor functions.
Naomi Levy-Strumpf; Joseph G Culotti
Related Documents :
9001707 - Cellular localisation of metabotropic glutamate receptors in the mammalian optic nerve:...
17314307 - Deletion of nf1 in neurons induces increased axon collateral branching after dorsal roo...
17610877 - Rewiring the injured cns: lessons from the optic nerve.
10499167 - The deleted in colorectal cancer netrin guidance system: a molecular strategy for neuro...
16480817 - Identification and localisation of the nr1 sub-unit homologue of the nmda glutamate rec...
15257307 - Mu-opioid receptors are not involved in acute cocaine-induced locomotor activity nor in...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-01-21
Journal Detail:
Title:  Nature neuroscience     Volume:  10     ISSN:  1097-6256     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-29     Completed Date:  2007-04-03     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  161-8     Citation Subset:  IM    
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Axons / metabolism*,  ultrastructure
Caenorhabditis elegans
Caenorhabditis elegans Proteins / genetics,  metabolism*
Cell Adhesion Molecules / genetics,  metabolism*
Cell Differentiation / physiology
Cell Movement / physiology*
Cell Polarity / physiology
Gene Expression Regulation, Developmental / physiology
Monomeric GTP-Binding Proteins / genetics,  metabolism
Nerve Growth Factors / metabolism
Nerve Tissue Proteins / genetics,  metabolism*
Nervous System / cytology,  embryology,  metabolism
Neural Pathways / cytology,  embryology,  metabolism
Receptors, Immunologic / genetics,  metabolism
Receptors, Nerve Growth Factor / metabolism
rac GTP-Binding Proteins / genetics,  metabolism*
Grant Support
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Cell Adhesion Molecules; 0/Nerve Growth Factors; 0/Nerve Tissue Proteins; 0/Receptors, Immunologic; 0/Receptors, Nerve Growth Factor; 0/UNC-40 protein, C elegans; 0/UNC-6 protein, C elegans; 0/UNC-73 protein, C elegans; 0/VAB-8 protein, C elegans; 0/roundabout protein; EC 3.6.1.-/Mig-2 protein, C elegans; EC GTP-Binding Proteins; EC GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inducing motor skill improvements with a declarative task.
Next Document:  C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations.