Document Detail


VZV multifocal vasculopathy with ischemic optic neuropathy, acute retinal necrosis and temporal artery infection in the absence of zoster rash.
MedLine Citation:
PMID:  23312850     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe a 54-year-old diabetic woman who developed ischemic optic neuropathy followed by acute retinal necrosis and multiple areas of focal venous beading. Vitreous fluid contained amplifiable VZV DNA but not HSV-1, CMV or toxoplasma DNA. The clinical presentation was remarkable for jaw claudication and intermittent scalp pain, prompting a temporal artery biopsy that was pathologically negative for giant cell arteritis, but notable for VZV antigen. The current case adds to the clinical spectrum of multifocal VZV vasculopathy. The development of acute VZV retinal necrosis after ischemic optic neuropathy supports the notion that vasculitis is an important additional mechanism in the development of VZV retinal injury.
Authors:
Marc Mathias; Maria A Nagel; Nelly Khmeleva; Philip J Boyer; Alexander Choe; Vikram D Durairaj; Jeffrey L Bennett; Naresh Mandava; Don Gilden
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-11
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  325     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-10-21     Revised Date:  2014-02-18    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  180-2     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Exanthema*
Female
Herpes Zoster / complications,  diagnosis*
Herpesvirus 3, Human*
Humans
Optic Neuropathy, Ischemic / complications,  diagnosis*
Retinal Necrosis Syndrome, Acute / complications,  diet therapy*
Temporal Arteries / pathology,  virology*
Grant Support
ID/Acronym/Agency:
AG006127/AG/NIA NIH HHS; AG032958/AG/NIA NIH HHS; K08 NS067070/NS/NINDS NIH HHS; NS067070/NS/NINDS NIH HHS; P01 AG032958/AG/NIA NIH HHS; R01 AG006127/AG/NIA NIH HHS
Comments/Corrections

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