| VIVID interacts with the WHITE COLLAR complex and FREQUENCY-interacting RNA helicase to alter light and clock responses in Neurospora. | |
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MedLine Citation:
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PMID: 20807745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The photoreceptor and PAS/LOV protein VIVID (VVD) modulates blue-light signaling and influences light and temperature responses of the circadian clock in Neurospora crassa. One of the main actions of VVD on the circadian clock is to influence circadian clock phase by regulating levels of the transcripts encoded by the central clock gene frequency (frq). How this regulation is achieved is unknown. Here we show that VVD interacts with complexes central for circadian clock and blue-light signaling, namely the WHITE-COLLAR complex (WCC) and FREQUENCY-interacting RNA helicase (FRH), a component that complexes with FRQ to mediate negative feedback control in Neurospora. VVD interacts with FRH in the absence of WCC and FRQ but does not seem to control the exosome-mediated negative feedback loop. Instead, VVD acts to modulate the transcriptional activity of the WCC. |
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Authors:
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Suzanne M Hunt; Seona Thompson; Mark Elvin; Christian Heintzen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-31 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-22 Completed Date: 2010-11-02 Revised Date: 2011-07-26 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 16709-14 Citation Subset: IM |
Affiliation:
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Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Base Sequence Cell Nucleus / metabolism Circadian Rhythm / genetics, physiology* Cytoplasm / metabolism DNA-Binding Proteins / genetics, physiology* Feedback, Physiological Fungal Proteins / genetics, physiology* Gene Expression Regulation, Fungal Genes, Fungal Light Models, Biological Neurospora crassa / genetics, physiology*, radiation effects* Photoreceptors, Microbial / genetics, physiology RNA Helicases / genetics, physiology* RNA, Fungal / genetics, metabolism RNA, Messenger / genetics, metabolism Signal Transduction Transcription Factors / genetics, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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BB/D00988X/1//Biotechnology and Biological Sciences Research Council; BB/F012055/1//Biotechnology and Biological Sciences Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Fungal Proteins; 0/Photoreceptors, Microbial; 0/RNA, Fungal; 0/RNA, Messenger; 0/Transcription Factors; 0/VVD protein, Neurospora crassa; 0/wc-1 protein, Neurospora crassa; 0/white collar 2 protein, Neurospora; EC 2.7.7.-/RNA Helicases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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