| VIPoma syndrome: challenges in management. | |
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MedLine Citation:
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PMID: 20730389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vasoactive intestinal peptide-producing tumour (VIPoma) or Verner-Morrison syndrome is a very rare neuroendocrine tumour. It occurs in less than ten percent of all pancreatic islet cell tumours, and about 70 percent to 80 percent of these tumours originate from the pancreas. Diagnosis is characteristically delayed. The first-line treatment is surgical. It may be curative in forty percent of patients with benign and non-metastatic disease. Palliative surgery is indicated in extensive disease, followed by conventional somatostatin analogue (octreotide) therapy. Somatostatin analogues improve hormone-mediated symptoms, reduce tumour bulk and prevent local and systemic effects. We present a female patient with VIPoma syndrome, which had metastasised to the liver at diagnosis. The patient underwent palliative Whipple procedure and subsequent cytoreductive radiofrequency ablations to her liver metastases. Unfortunately, after symptomatic improvement for three years, her disease progressed. Currently, she is on daily octreotide, achieving partial control of her symptoms. |
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Authors:
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N Adam; S S Lim; V Ananda; S P Chan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Singapore medical journal Volume: 51 ISSN: 0037-5675 ISO Abbreviation: Singapore Med J Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404516 Medline TA: Singapore Med J Country: Singapore |
Other Details:
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Languages: eng Pagination: e129-32 Citation Subset: IM |
Affiliation:
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Endocrine Unit, Department of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur 50603, Malaysia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Catheter Ablation
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methods Combined Modality Therapy Disease Progression Female Follow-Up Studies Humans Liver Neoplasms / secondary*, surgery Middle Aged Neoplasm Invasiveness / pathology Neoplasm Staging Octreotide / therapeutic use Palliative Care* / methods Pancreatic Neoplasms / pathology*, therapy Time Factors Treatment Outcome Vipoma / pathology, secondary*, therapy |
| Chemical | |
Reg. No./Substance:
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83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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